| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| SMAD4 | SMAD family member 4 | Transcription Factor | Insensitivity to Anti-Growth Signal | Tumor Suppression | miR-888 expressions are increased in advanced prostate cancer and miR-888 targets and lowers the expression levels of tumour suppressor SMAD4. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Insensitivity to Anti-Growth Signal | Tumor Suppression | SMAD4 is a tumor suppressor located on chromosome 18q21.1 and its expression levels are reduced in prostate cancer tissues compared to normal prostate. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Self-Sufficiency in Growth Signal | Cell Proliferation | SMAD4 inactivation accelarates prostate cancer cell proliferation | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Genome Instability, Mutation & Perturbation | Methylation | Promoter methylation of SMAD4 is associated with reduced expression in prostate cancer. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Metastasis | Metastasis | Reduced SMAD4 expression play an important role in prostate cancer metastasis. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Metastasis | Metastasis | SMAD4 inactivation is associated with metastasis progression in prostate cancer and SMAD4 is an important regulator of prostate cancer development. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Metastasis | Epithelial Mesenchymal Transition(EMT) | SMAD4 is involved in prostate cancer epithelial mesenchymal transition through TGFbeta/BMP-SMAD4 signaling pathway. | Reference |
| SMAD4 | SMAD family member 4 | Transcription Factor | Androgen Receptor Signalling | AR Signaling | SMAD4 plays a very crucial role in human prostate cancer initiation & progresion through direct physical interaction with androgen receptor (AR). | Reference |