| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Insensitivity to Anti-Growth Signal | Tumor Suppression | TGF beta induced SMAD3 mediated signaling have a tumor suppressive activity in castration resistant prostate cancer. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Self-Sufficiency in Growth Signal | Cell Growth | SMAD3 play a critical role in prostate cancer cell growth in androgen-independent PC-3MM2 prostate cancer cells | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Genome Instability, Mutation & Perturbation | Overexpression | SMAD3 is overexpressed in human prostate cancer and its expression correlates with gleason score. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Angiogenesis | Angiogenesis | SMAD3 functions as a critical angiogenesis switch and regulates the expression of several angiogenic molecules in androgen independent prostate cancer cell lines. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Metastasis | Cell Invasion | Mediates prostate cancer bone metastasis through activin A-AR-SMAD3 signaling and cell invasion in a TGFBR1-SMAD3-PI3K dependent signaling. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Metastasis | Cell Motility | SMAD3 is associated with prostate cancer cell adhesion as a mediator of growth and differentiation factor-9(GDF-9) dependent signaling and activation of FAK and paxillin in PC-3 prostate cancer cells. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Metastasis | Cell Adhesion | SMAD3 is associated with prostate cancer cell adhesion as a mediator of growth and differentiation factor-9(GDF-9) dependent signaling and activation of FAK and paxillin in PC-3 prostate cancer cells. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Metastasis | Cell Migration | SMAD3 is associated with the prostate cancer cell invasion through TGFBR1-SMAD3-PI3-kinase signaling. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Metastasis | Bone Metastasis | SMAD3 play an important role in the activation of AR and Activin A-AR-SMAD3 signaling axis is involved in prostate cancer bone metastasis. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | Metastasis | Cell Invasion | It is involved in prostate cancer cell invasion in androgen independent prostate cancer cell line. | Reference |