| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Insensitivity to Anti-Growth Signal | Tumor Suppression | RAC1 is involved in Cyclin D1 mediated cell cycle regulation through PAK1 in androgen independent prostate cancer cell. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Self-Sufficiency in Growth Signal | Cell Survival | RAC1 is associated with prostate cancer cell survival through AKT mediated pathway. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Self-Sufficiency in Growth Signal | Cell Proliferation | RAC1 play an important role in androgen independent prostate cancer cell proliferation, supported by both in vitro and in vivo experiments | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Metastasis | Metastasis | RAC1 is involved in prostate cancer metastasis through EPHA2-VAV3-RAC1 signaling axis. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Metastasis | Cell Motility | RAC1 is involved in prostate cancer cell motility driven by 14-3-3 zita dimerization. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Metastasis | Cell Adhesion | RAC1 plays an important role in human prostate cancer cell adhesion. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Metastasis | Cell Migration | RAC1 is involved in prostate cancer cell migration through actin polymerization and filopedia formation | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Metastasis | Cell Migration | TROP2 modulates RAC1 and enhance prostate cancer cell migration. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Metastasis | Bone Metastasis | RAC1 is an important mediator of prostate cancer cell-bone marrow endothelial cell interactions. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Metastasis | Bone Metastasis | RAC1 play an important role in prostate cancer bone metastasis and enhancing prostate cancer cell homing and entry into bone. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Angiogenesis | Angiogenesis | It is involved in a complex formation downstream of NADPH oxidase and there by triggers prostate cancer angiogenesis through HIF1alpha mediated manner. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | Androgen Independence | Androgen Independence | RAC1 activation plays a leading role in androgen independent prostate cancer cell proliferation and ther by promotes the development of androgen independence. | Reference |