Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
DAB2Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)Adaptor ProteinInsensitivity to Anti-Growth SignalTumor SuppressionDAB2 functions as a potent tumour suppressor in prostate cancer; functions as a negative regulator of cell growth.Reference
DAB2Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)Adaptor ProteinSelf-Sufficiency in Growth SignalCell ProliferationPKC mediated phosphorylation of DAB2 protein regulates its inhibitory function in cell proliferationReference
DAB2Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)Adaptor ProteinSelf-Sufficiency in Growth SignalCell GrowthDAB2 mediated signaling is involved in the modulation of androgen mediated cell growth in both normal and malignant prostate epithelial cellsReference
DAB2Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)Adaptor ProteinGenome Instability, Mutation & PerturbationLoss of ExpressionIn many prostate cancer cell line, DAB2 suffers from loss of expressionReference
DAB2Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)Adaptor ProteinMetabolic ReprogrammingMetabolic ReprogrammingDAB2 along with Megalin plays an essential role in the transport of Vidamin D 25-hydroxycholecalciferol (25D3)-vitamin D binding protein (DBP) complex in prostate cancer cells.Reference

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