Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
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DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | Insensitivity to Anti-Growth Signal | Tumor Suppression | DAB2 functions as a potent tumour suppressor in prostate cancer; functions as a negative regulator of cell growth. | Reference |
DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | Self-Sufficiency in Growth Signal | Cell Proliferation | PKC mediated phosphorylation of DAB2 protein regulates its inhibitory function in cell proliferation | Reference |
DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | Self-Sufficiency in Growth Signal | Cell Growth | DAB2 mediated signaling is involved in the modulation of androgen mediated cell growth in both normal and malignant prostate epithelial cells | Reference |
DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | Genome Instability, Mutation & Perturbation | Loss of Expression | In many prostate cancer cell line, DAB2 suffers from loss of expression | Reference |
DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | Adaptor Protein | Metabolic Reprogramming | Metabolic Reprogramming | DAB2 along with Megalin plays an essential role in the transport of Vidamin D 25-hydroxycholecalciferol (25D3)-vitamin D binding protein (DBP) complex in prostate cancer cells. | Reference |