| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| BIN1 | Bridging integrator 1 | Adaptor Protein | Insensitivity to Anti-Growth Signal | Tumor Suppression | BIN1 is the chromosome 2q prostate tumour suppressor gene and frequently deleted in metastatic prostate cancer; Its inactivation contributes to the enhancement of c-MYC mediated oncogenic function . | Reference |
| BIN1 | Bridging integrator 1 | Adaptor Protein | Self-Sufficiency in Growth Signal | Cell Growth | Functions as a prostate cancer cell growth suppressor. | Reference |
| BIN1 | Bridging integrator 1 | Adaptor Protein | Genome Instability, Mutation & Perturbation | Epigenetic Silencing | BIN1 gene promoter CpG island is frequently methylated and epigenetically inactivated in prostate cancer | Reference |
| BIN1 | Bridging integrator 1 | Adaptor Protein | Genome Instability, Mutation & Perturbation | Aberrant Splicing | BIN1 is most frequently inactivated by aberrant splicing in metastatic tumours. | Reference |
| BIN1 | Bridging integrator 1 | Adaptor Protein | Cell Death Resistance | Apoptosis Evasion | BIN1 is a proapoptotic molecule that can regulate prostate cancer progression and is frequently inactivated in prostate cancer | Reference |