| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Self-Sufficiency in Growth Signal | Cell Survival | 14-3-3 zeta (YWHAZ) interacts with AR and promotes prostate cancer cell survival in an androgen responsive way | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Genome Instability, Mutation & Perturbation | Gene Amplification | YWHAZ is amplified in castration resistant prostate cancer | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Metastasis | Cell Motility | 14-3-3zeta enhances prostate cancer cell-matrix interactions, motility and transendothelial migration via activation of Rac1-GTPase | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Metastasis | Cell Migration | 14-3-3zeta enhances prostate cancer cell-matrix interactions, motility and transendothelial migration in vitro via activation of Rac1-GTPase | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Metastasis | Cell Proliferation | 14-3-3 zeta (YWHAZ) interacts with AR and promotes prostate cancer cell proliferation in an androgen responsive way | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | Androgen Receptor Signalling | AR Signaling | 14-3-3 (YWHAZ), an adapter protein which is under the transcriptional regulation of androgen receptor (AR), plays a role in human prostate tumorigenesis through activation of cell proliferation and migration. | Reference |