| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Self-Sufficiency in Growth Signal | Cell Growth | FHL2 is associated with constitutive activation of AR-mediated growth signals in prostate cancer | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Genome Instability, Mutation & Perturbation | Overexpression | FHL2 is overexpressed in prostate cancer | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Metastasis | Cell Migration | Promotes cell migration in androgen independent PC-3 prostate cancer cell line and its activity is regulated by Ets-1; an androgen co regulator | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Cell Death Resistance | Apoptosis Evasion | It inhibits FOXO1 activity & there by suppresses the genes involved in apoptosis in both androgen dependent & independent prostate cancer cell line. | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Castration Resistance | Castration Resistance | Adaptor protein FHL2 plays a role in castration resistant prostate cancer (CRPC) progression through transcriptional coactivation of androgen receptor (AR) variants AR-V7. | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | Androgen Independence | Androgen Independence | FHL2, an adaptor protein and a critical transcriptional coactivator, plays a very important role in activation of androgen receptor(AR) and there by promotes androgen independent prostate cancer progression. | Reference |