| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Tumour Microenvironment | Cancer Microenvironment | BMP7-BMPR2-p38-NDRG1 axis plays an important role in dormancy and recurrence of prostate CSC(cancer stem like cell)s in bone | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Tumour Microenvironment | Cancer Microenvironment | BMPR2 and CXCR4 are involved in heterotypic cell-cell interaction mediated by both autocrine and paracrine way | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Tumour Microenvironment | | BMP7-BMPR2-p38-NDRG1 axis plays an important role in dormancy and recurrence of prostate CSC(cancer stem like cell)s in bone | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Tumour Microenvironment | | BMPR2 and CXCR4 are involved in heterotypic cell-cell interaction mediated by both autocrine and paracrine way | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Insensitivity to Anti-Growth Signal | Tumor Suppression | BMP-9 is a putative tumor suppressor in prostate cancer and and in thses functional context BMPR2 is required for its function | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Insensitivity to Anti-Growth Signal | Tumor Suppression | BMP-9 is a putative tumor suppressor in prostate cancer and BMPR2 is required for its function | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Self-Sufficiency in Growth Signal | Cell Survival | BMPR2 promotes prostate cancer cell survival | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Self-Sufficiency in Growth Signal | Cell Growth | Knock down of BMPR2 receptor enhance in vitro cell growth in prostate cancer PC3 cell. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Genome Instability, Mutation & Perturbation | Loss of Expression | Loss of BMPR2 expression is responsible for prostate cancer pathogenesis, loss of BMP-RII function may result in increased tumorigenicity in human prostate cancer cells | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Metastasis | Metastasis | Involved in osteoblastic metastasis in prostate cancer, bone metastasis in prostate cancer | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Metastasis | Cell Invasion | It is involved in the regulation of endoglin mediated suppression of prostate cancer cell invasion. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Metastasis | Cell Adhesion | BMP9 causes in vitro inhibition of cell adhesion in prostate cancer and BMPR2 is required for its function | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Metastasis | Cell Migration | BMP9 causes in vitro inhibition of cell migration in prostate cancer and BMPR2 is required for its function | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Cell Death Resistance | Aoptosis Resistance | BMP9 function as apoptosis regulator and BMPR2 is required for its function in prostate cancer. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Cell Death Resistance | Modulation of Cell Death Mechinery | BMP9 function as apoptosis regulator and BMPR2 is required for its function in prostate cancer. | Reference |
| BMPR2 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) | Receptor Serine/threonine Kinase | Metastasis | Cell Invasion | Mediates osteoblastic metastasis in prostate cancer ; regulates prostate cancer cell invasion. | Reference |