| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Growth | Mediates prostate cancer cell growth regulation in androgen dependent prostate cancer cell line; phosphorylated by prostatic acid phosphatase (cPAcP); involved in castration resistance. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Self-Sufficiency in Growth Signal | Cell Proliferation | Both EGFR and ERBB2 is involved in prostate cancer cell proliferation. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Tumor Promoting Inflammation | Inflammation pathway | ERBB2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Genome Instability, Mutation & Perturbation | Overexpression | HER-2/neu(ERBB2) is overexpressed in androgen independent prostate cancer and is linked with tumour stage and Gleason score. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Metastasis | Cell Invasion | ERBB2 is involved in prostate cancer cell invasion through ERBB2-P3K-Matripase signaling pathway. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Metastasis | Cell Adhesion | ERBB2 is involved with prostate cancer cell adhesion through ERBB2-PYK2-ERK/MAPK pathway in androgen responsive prostate cancer cell line. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Metastasis | Bone Metastasis | It is involved in prostate cancer bone metastasis and is trans-activated by CXCL12/CXCR4 axis. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Androgen Receptor Signalling | AR Signaling | ERBB2 receptor, which is overexpressed in human prostate cancer, plays an imortant role in activation of androgen receptor (AR) mediated signaling, and there by significantly promotes human prostate cancer progression. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | Genome Instability, Mutation & Perturbation | Gene Amplification | ERBB2 (HER2) gene amplification has been reported in human prostate cancer which is associated with cancer progression, poor prognosis or development of androgen independence. | Reference |