Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
NGFRNerve growth factor receptorCell Surface ReceptorInsensitivity to Anti-Growth SignalTumor SuppressionNGFR(p75NTR) tumour suppressor is lost during prostate cancer progression and is involved in regulation of apoptosis via intrinsic mitochondrial pathway.Reference
NGFRNerve growth factor receptorCell Surface ReceptorSelf-Sufficiency in Growth SignalCell SurvivalNGFR(p75NTR) and its ligand NGFR is involved in pro survival signaling in prostate cancer.Reference
NGFRNerve growth factor receptorCell Surface ReceptorGenome Instability, Mutation & PerturbationLoss of Expression3' UTR are involved in loss of p75(NTR) expression in prostate cancer.Reference
NGFRNerve growth factor receptorCell Surface ReceptorMetastasisMetastasisNGFR(p75NTR) functions as a metastatic suppressor in prostate cancer by down regulation of uPA, MMP-2, MMP-9, and TIMP-1.Reference
NGFRNerve growth factor receptorCell Surface ReceptorMetastasisCell InvasionNGFR(p75NTR) re-expression in stromal smooth muscle cells is related to the prostate cancer tumour cell invasion.Reference
NGFRNerve growth factor receptorCell Surface ReceptorMetastasisCell MigrationNGFR(p75NTR) is involved in prostate cancer cell migration via NGFR(p75NTR)-P38mapk-nag1 pathway.Reference
NGFRNerve growth factor receptorCell Surface ReceptorCell Death ResistanceApoptosis EvasionIt is involved in intrinsic apoptosis cascade & its loss of expression is associated with apoptosis evasion in androgen independent prostate cancer cell line.Reference
NGFRNerve growth factor receptorCell Surface ReceptorInsensitivity to Anti-Growth SignalTumor SuppressionNGFR [p75(NTR)], a tumour suppressor which is lost during the course of prostate tumorigenesis, plays a significant role in regulation of prostate cancer cell cycle.Reference

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