| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| AR | Androgen receptor | Nuclear Receptor | Tumour Microenvironment | Cancer Microenvironment | ability of epithelial cells to modulate coregulator recruitment to the AR transcriptional complex on androgen-responsive genes seems altered in the stromal microenvironment of prostate cancer | Reference |
| AR | Androgen receptor | Nuclear Receptor | Tumour Microenvironment | Cancer Microenvironment | Inflammatory cytokines and chemokines released by macrophages in the prostate cancer microenvironment may signal via the androgen receptor (AR) to influence tumor progression | Reference |
| AR | Androgen receptor | Nuclear Receptor | Self-Sufficiency in Growth Signal | Cell Survival | AR transcriptionally activate 14-3-3zeta and through its action enhances prostate cancer cell survial & proliferation | Reference |
| AR | Androgen receptor | Nuclear Receptor | Self-Sufficiency in Growth Signal | Cell Growth | Ar is involved in prostate cancer cell growth via AMPK-PGC-1alpha signaling cascade, a known homeostatic mechanism, to increase prostate cancer cell growth | Reference |
| AR | Androgen receptor | Nuclear Receptor | Self-Sufficiency in Growth Signal | Cell Growth | Regulates prostate cancer cell growth through a metabolic switch; promotes growth through ELK1; enhance cell growth through a ternary membrane associated complex with c-Src. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Self-Sufficiency in Growth Signal | Cell Proliferation | Cell proliferation is linked to ribosome biogenesis which is stimulated by AR and Estrogen receptor signaling in prostate cancer | Reference |
| AR | Androgen receptor | Nuclear Receptor | Tumor Promoting Inflammation | | alteration of signaling of macrophage androgen receptor (AR)-inflammatory chemokine CCL4-STAT3 activation is involved in prostate cancer inflammation | Reference |
| AR | Androgen receptor | Nuclear Receptor | Tumor Promoting Inflammation | Inflammation | Modulation of AR-CCL4-STAT3 axis by infiltrating macrophage play an important role in prostate tumour inflammation. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Genome Instability, Mutation & Perturbation | Mutation | Mutation in Androgen receptor causes relaxation of AR ligand specificity | Reference |
| AR | Androgen receptor | Nuclear Receptor | Genome Instability, Mutation & Perturbation | Gene Amplification | Androgen receptor (AR) gene as a target gene for the Xq12 amplification found in one-third of the hormone-refractory prostate cancer | Reference |
| AR | Androgen receptor | Nuclear Receptor | Genome Instability, Mutation & Perturbation | Aberrant Splicing | Androgen receptor splice variants AR3 is the most abundantly expressed variants that propels tumorigenesis under androgen deprivation condition | Reference |
| AR | Androgen receptor | Nuclear Receptor | Angiogenesis | Angiogenesis | AR mediates prostate cancer angiogenesis through VEGF expression by AR-SP1 complex formation. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Angiogenesis | Angiogenesis | Targeting AR signaling inhibit the wound healing process by altering macrophage infiltration as well as cytokine expressiopn profile | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Metastasis | Endothelial cells augments prostate cancer metastasis via IL-6?androgen receptor?TGF-beta?MMP-9 signaling pathway | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Cell Invasion | Mediates prostate cancer cell invasion by endothelial cells through IL-6-AR-TGFbeta-MMP9 signaling. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Cell Motility | Androgen receptor is involved in prostate cancer cell motility through SRC-FAK-PI3K-CDC42-RAC1 cascade. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Cell Motility | Androgen receptor stimulates PAK6 by direct interaction and PAK6 activation enhance prostate cancer cell motility & Cell Invasion | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Cell Motility | Androgen receptor stimulates PAK6 by direct interaction and PAK6 activation enhance prostate cancer cell motility & invasion | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Epithelial Mesenchymal Transition(EMT) | Androgen receptor mediated signaling is responsible for epithelial mesenchymal transition in prostate epithelial cells | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Epithelial Mesenchymal Transition(EMT) | Androgen receptor mediated signaling is responsible for epithelial mesenchymal transition in prostate epithelial cells | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Cell Migration | Androgen receptor play an important role in prostate cancer cell migration through activin A-Smad-AR axis. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Cell Migration | Androgen receptor target gene TM4SF1 is overexpressed in human prostate cancer and is involved in prostate cancer cell migration | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Cell Migration | AR/FlnA/integrin beta 1 complex is the key by which androgen activates signaling leading to prostate cancer cell migration | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Cell Proliferation | Cell proliferation is linked to ribosome biogenesis which is stimulated by AR and Estrogen receptor signaling in prostate cancer | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Death Resistance | Radioresistance | androgen receptor signaling transcriptionally upregulates a large subset of DNA repair genes, thereby enhancing the repair capacity and promoting radioresistance of prostate cancer | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Death Resistance | Chemoresistance | It is critically involved in multidrug resistance including docetaxel resistance in prostate cancer through crosstalking with Twist1/YB-1 signalling. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Death Resistance | Modulation of Cell Death Mechinery | AR enhance prostate cancer progression by differential modulation of various cell deaths including apoptosis, anoikis, entosis, necrosis, and autophagic cell deaths | Reference |
| AR | Androgen receptor | Nuclear Receptor | Enabling Replicative Immortality | Telomere maintenance | In human cancer telomerase activation can be blocked by anti androgen through suppressing AR signaling | Reference |
| AR | Androgen receptor | Nuclear Receptor | Self-Sufficiency in Growth Signal | Cell Growth | Mediates PAK6 activation and associated with prostate cancer cell growth. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Epithelial Mesenchymal Transition(EMT) | It promotes prostate cancer metastasis by regulating EMT. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metastasis | Epithelial Mesenchymal Transition(EMT) | Androgen deprivation therapy mediates prostate cancer EMT through a feed back loop involving AR and Zeb1 transcription factor. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Cell Death Resistance | Chemoresistance | It mediates enzalutamide resistance through NF-?B2/p52 signaling in androgen dependent prostate cancer cell line. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | Metabolic Reprogramming | AR regulates liver X receptor(LXR) activity and thereby mediates cholesterol accumulation in prostate cancer cell. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | Metabolic Reprogramming | AR-AMPK-PGC-1alpha signaling cascade mediates mitochondrial biogenesis in prostate cancer cell and consequently effects prostate cancer cell growth along with metabolic reprogramming | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | Metabolic Reprogramming | AR promotes prostate cancer metabolic reprogramming by influencing pentose phosphate pathway in prostate cancer through mammalian target of rapamycin (mTOR)-mediated upregulation of glucose-6-phosphate dehydrogenase (G6PD). | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | Metabolic Reprogramming | AR plays a cetralmost role in prostate cancer metabolic reprogramming through upregulation of glucose uptake and glycolysis(GLUT1, HK1/2 and PFKFB2) and lipid biosynthetic pathways(FASN and ACACA). | Reference |
| AR | Androgen receptor | Nuclear Receptor | Metabolic Reprogramming | Metabolic Reprogramming | AR along with JunD mediates an oxidative stress(ROS) generation pathway in prostate cancer and thereby promotes metabolic reprogramming through polyamine oxidation. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Tumour Microenvironment | Cancer Microenvironment | Androgen receptor(AR) in the prostate tumour microenvironment epigenetically suppressed SPARCL1 and there by promotes metastasis. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Tumour Microenvironment | Cancer Microenvironment | AR mediated signaling in prostate myofibroblasts plays an important role in stromal-mediated alterations to the ECM and microenvironment. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Tumour Microenvironment | Cancer Microenvironment | Androgen receptor(AR) in the prostate cancer associated fibroblast (CAF) plays an important role in regulating the expression of series of growth factors which are associated with cell growth and invasions. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Avoidance of Immune Destruction | Immuno Suppression | Androgen receptor plays an important role in the inhibition of CD4+T cell to Th1 differentiation and there by promotes immunosuppression in prostate tumour associated microenvironment. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Insensitivity to Anti-Growth Signal | Cell Cycle | Androgen receptor(AR) plays a very crucial role in androgen independent prostate cancer cell cycle progression through upregulation of M-phase cell cycle genes. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Castration Resistance | Castration Resistance | Androgen receptor (AR) plays a critical transcriptional regulatory role in the development of castration resistant prostate cancer (CRPC). | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen Independence | Androgen Independence | Androgen receptor (AR) itself mediates androgen independent prostate cancer cell growth through upregulation of c-MYC oncogene. | Reference |