Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
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VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Self-Sufficiency in Growth Signal | Cell Growth | VAV3 is involved in prostate cancer cell growth in LNCaP prostate cancer cell line. | Reference |
VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Genome Instability, Mutation & Perturbation | Overexpression | VAV3 is overexpressed in androgen-independent prostate cancer. | Reference |
VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Metastasis | Cell Invasion | VAV3 is associated with prostate cancer cell invasion through ephrinA1-EphA2-Vav3-Rac1 signaling axis. | Reference |
VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Metastasis | Cell Migration | VAV3 is associated with prostate cancer cell migration through ephrinA1-EphA2-Vav3-Rac1 signaling axis. | Reference |
VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Castration Resistance | Castration Resistance | VAV3, a Rho GTPase guanine nucleotide exchange factor that is highly expressed in human prostate cancer, plays a role in castration resistant prostate cancer (CRPC) cell growth through coactivation of androgen receptor(AR). | Reference |
VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Androgen Receptor Signalling | AR Signaling | VAV3, a Rho GTPase guanine nucleotide exchange factor that is overexpressed in human prostate cancer plays a role in prostate cancer cell proliferation through activation of androgen receptor (AR) mediated signaling. | Reference |
VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | Androgen Independence | Androgen Independence | VAV3, which is overexpressed in castration resistant prostate cancer, plays a very important role in androgen independent prostate cancer cell growth and cell survival through enhancement of androgen independent splice variant (AR3) activity. | Reference |