Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
VAV3Vav 3 guanine nucleotide exchange factorGuanine Nucleotide Exchange FactorSelf-Sufficiency in Growth SignalCell GrowthVAV3 is involved in prostate cancer cell growth in LNCaP prostate cancer cell line.Reference
VAV3Vav 3 guanine nucleotide exchange factorGuanine Nucleotide Exchange FactorGenome Instability, Mutation & PerturbationOverexpressionVAV3 is overexpressed in androgen-independent prostate cancer.Reference
VAV3Vav 3 guanine nucleotide exchange factorGuanine Nucleotide Exchange FactorMetastasisCell InvasionVAV3 is associated with prostate cancer cell invasion through ephrinA1-EphA2-Vav3-Rac1 signaling axis.Reference
VAV3Vav 3 guanine nucleotide exchange factorGuanine Nucleotide Exchange FactorMetastasisCell MigrationVAV3 is associated with prostate cancer cell migration through ephrinA1-EphA2-Vav3-Rac1 signaling axis.Reference
VAV3Vav 3 guanine nucleotide exchange factorGuanine Nucleotide Exchange FactorCastration ResistanceCastration ResistanceVAV3, a Rho GTPase guanine nucleotide exchange factor that is highly expressed in human prostate cancer, plays a role in castration resistant prostate cancer (CRPC) cell growth through coactivation of androgen receptor(AR).Reference
VAV3Vav 3 guanine nucleotide exchange factorGuanine Nucleotide Exchange FactorAndrogen Receptor SignallingAR SignalingVAV3, a Rho GTPase guanine nucleotide exchange factor that is overexpressed in human prostate cancer plays a role in prostate cancer cell proliferation through activation of androgen receptor (AR) mediated signaling.Reference
VAV3Vav 3 guanine nucleotide exchange factorGuanine Nucleotide Exchange FactorAndrogen IndependenceAndrogen IndependenceVAV3, which is overexpressed in castration resistant prostate cancer, plays a very important role in androgen independent prostate cancer cell growth and cell survival through enhancement of androgen independent splice variant (AR3) activity.Reference

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