| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Self-Sufficiency in Growth Signal | Cell Survival | Play a role in osteopontin mediated prostate cancer cell survival in androgen dependent & independent prostate cancer cell line. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Self-Sufficiency in Growth Signal | Cell Growth | Beta catenine(CTNNB1) is involved in prostate cancer cell growth as inhibitor targeting beta catenine suppressed prostate cancer cell growth. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Self-Sufficiency in Growth Signal | Cell Proliferation | Beta catenine(CTNNB1) is associated with prostate cancer cell proliferation as lupeol targets beta catenine and inhibits proliferation of prostate cancer cell. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metastasis | Cell Invasion | Beta catenine(CTNNB1) is associated invasion of prostate cancer cells. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metastasis | Epithelial Mesenchymal Transition(EMT) | Beta catenine is associated with epithelial mesenchymal transition in prostate cancer development mediated by SOX2. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metastasis | Epithelial Mesenchymal Transition(EMT) | Beta catenine is involved in the epithelial mesenchymal transition of prostate cancer stem cell through HIF-1alpha/beta-catenin-dependent signaling pathway. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metastasis | Cell Migration | Beta catenine is involved in the migration of prostate cancer stem cell through HIF-1alpha/beta-catenin-dependent signaling pathway. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metastasis | Bone Metastasis | Beta catenine over expression is related to prostate cancer bone metastasis. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Self-Sufficiency in Growth Signal | Cell Survival | Disruption of reciprocal balance between the beta-cat/Tcf and the beta-cat/AR pathways results in prostate cancer cell survival. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Self-Sufficiency in Growth Signal | Cell Proliferation | Involved in prostate cancer cell proliferation in androgen independent PC-3 and DU-145 prostate cancer cell line. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metastasis | Cell Motility | Influences prostate cancer cell motility through E-cadherin and PKD1. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metastasis | Epithelial Mesenchymal Transition(EMT) | EPLIN downregulation in metastatic prostate cancer results in the activation of beta catenine mediated pro-EMT gene expression. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metabolic Reprogramming | Metabolic Reprogramming | CTNNB1 plays a very important role in prostate cancer metabolic reprogramming by regulating the expression of HIF1A, which is a master transcription factor and inherently associated with prostate cancer warburg effect. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Metabolic Reprogramming | Metabolic Reprogramming | Fatty acid synthase (FASN), a key metabolic enzyme for liponeogenesis and overexpressed in prostate cancer, stabilizes cytoplasmic CTNNB1, which plays a leading role in prostate cancer metabolic reprogramming. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Castration Resistance | Castration Resistance | Beta-Catenin (CTNNB1), a key mediator of the canonical Wnt signaling pathway plays a leading role in the development and progression of castration resistant prostate cancer (CRPC) through interaction with androgen receptor (AR). | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Androgen Independence | Androgen Independence | Wnt/beta catenine mediated signaling is involved in the promotion of androgen independent prostate cancer cell growth. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Cell Death Resistance | Autophagy | Beta catenine (CTNNB1), a key signaling component in Wnt signaling pathway, plays a critical role in the inhibition of autophagy in human prostate cancer cell through nuclear accumulation in response of nitric oxide (NO). | Reference |