| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Insensitivity to Anti-Growth Signal | Cell Cycle | PLK1 is overexpressed in prostate cancer and associated with deregulation of cell cycle and mitotic entry. | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Insensitivity to Anti-Growth Signal | Cell Cycle | Polo-like kinase 1 (PLK1) is associated with mitotic mechinery in prostate cancer as Si RNA mediated silencing of PLK1 results in mitotic cell cycle arrest and defects in centrosome integrity. | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Self-Sufficiency in Growth Signal | Cell Proliferation | PLK1 plays an important role during mitotic entry of prostate cancer cell proliferation. | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Genome Instability, Mutation & Perturbation | Overexpression | Polo-like kinase 1 (PLK1) is overexpressed during prostate cancer development and asociated with higher tumour grade. | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Castration Resistance | Castration Resistance | Polo-like kinase 1 (PLK1), which is highly expressed in human prostate cancer, drives castration resistant prostate cancer (CRPC) through constitutive activation of androgen receptor (AR) signaling. | Reference |