Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseSelf-Sufficiency in Growth SignalCell GrowthSRC play an important role in prostate cancer cell growth through Src/FAK/Rho GTPase signaling pathway.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseAngiogenesisAngiogenesisSRC is involved in prostate cancer angiogenesis through Src/FAK/Rho GTPase mediated signaling in both androgen dependent & independent prostate cancer cell line..Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseMetastasisMetastasisSRC kinase is involved in prostate cancer metastasis by regulating the expression of E-cadherin demonstrated by tumour xenograft model.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseMetastasisCell MotilitySRC is involved in the prostate cancer cell motility along with FAK.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseMetastasisCell AdhesionMediates prostate cancer cell adhesion through beta(1) integrin-RACK1-FAK-SRC signaling pathway in androgen dependent and independent prostate cancer cell line.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseMetastasisCell MigrationSrc is involved in prostate cancer cell migration in a bradykinin dependent ways.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseMetastasisCell MigrationSRC is involved in prostate cancer cell migration in CCL2 and CCCR2 responsive ways mediated by PKCdelta, c-Src, and AP-1.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseMetastasisBone MetastasisSRC kinase play an important role in bone metastasis of prostate cancer.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseMetastasisLymph node MetastasisSRC is involved in lymph node metastasis during prostate cancer progression.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseCell Death ResistanceAoptosis ResistanceSRC is involved in apoptosis resistance in prostate cancer cell through P2Y2/Src/p38/COX-2 pathway.Reference
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologTyrosine KinaseMetastasisBone MetastasisIt is involved in prostate cancer bone metastasis by playing a role in osteoclast mediated bone resorption, tumour growth and metastasis.Reference

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