Human Prostrate Cancer Hallmarks Map



ProteinProtein NameMolecular TypeHallmarkFeatureEvidenceReference
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit betaLipid KinaseMetabolic ReprogrammingMetabolic ReprogrammingPIK3CB is involved in the metabolic regulation and glucose homeostasis in mouse prostate tumour model through a kinase independent mechanism.Reference
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit betaLipid KinaseSelf-Sufficiency in Growth SignalCell SurvivalInvolved in cell survival through AKT activation in both androgen dependent & independent prostate cancer cell line.Reference
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit betaLipid KinaseSelf-Sufficiency in Growth SignalCell GrowthPIK3CB is involved in prostate cancer cell growth through PIK3 pathway activation in PTEN deficient prostate tumour xenograft model.Reference
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit betaLipid KinaseSelf-Sufficiency in Growth SignalCell ProliferationPIK3CB is involved in prostate cancer abnormal cell proliferation through PIK3 pathway activation in PTEN deficient prostate tumour xenograft model.Reference

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