| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Metastasis | Epithelial Mesenchymal Transition(EMT) | Loss of DAB2IP is associated with prostate cancer epithelial mesenchymal transition , supported by experiments on human prostate xenograft-mouse model. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Cell Death Resistance | Chemoresistance | Its loss of expression contributes to docetaxel resistance in androgen dependent prostate cancer cell line. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Cell Death Resistance | Radioresistance | Loss of DAB2IP imparts prostate cancer cells to ionizing radiation resistance in androgen independent prostate cancer cell line. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Cell Death Resistance | Autophagy | It has a role in suppression of autophagy in androgen dependent & independent prostate cancer cell line. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Castration Resistance | Castration Resistance | Loss of DAB2IP expression, which functions as a key tumour suppressor in human prostate cancer, plays a very crucial role in promotion of castration resistant prostate cancer (CRPC) through mediating chemoresistance. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Cell Death Resistance | Apoptosis Evasion | DAB2IP, an important tumour suppressor which is lost during the progression of prostate cancer, reprograms intracellular signal transduction and inhibits prostate cancer apoptosis. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Cell Death Resistance | Radioresistance | DAB2IP, a potential tumor suppressor gene, is targeted by MiR-32 (overexpressed in human prostate cancer) and mediates radiation resistance in prostate cancer patially through suppression of autophagy related pathways. | Reference |
| DAB2IP | DAB2 interacting protein | Ras GTPase-activating protein | Cell Death Resistance | Autophagy | DAB2IP, a potential tumor suppressor gene which is largely inactivated in human prostate cancer, plays a very critical role in suppression of autophagy pathways in prostate cancer and in these context, MiR-32 overexpressed in human prostate cancer and mediates an important regulatory role. | Reference |