| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | Tumour Microenvironment | Cancer Microenvironment | PIM1 oncogene overexpressed in prostate fibroblat plays a crucial role in the differentiation of stromal fibroblasts into myofibroblasts by controlling both the transcription and translation of specific mRNAs. | Reference |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | Castration Resistance | Castration Resistance | PIM1 kinase, a serine/threonine kinase that is overexpressed in human prostate cancer, plays a role in the development of castration resistant prostate cancer (CRPC). | Reference |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | Androgen Receptor Signalling | AR Signaling | PIM1, which is overexpressed in advanced human prostate cancer, plays a role in prostate cancer cell survival through enhancement of AR transcriptional activity in a ligand-responsive manner. | Reference |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | Cell Death Resistance | Chemoresistance | PIM1 kinase, a serine/threonine kinase that is overexpressed in human prostate cancer, is involved in the development of docetaxel resistance in castration resistant prostate cancer cell. | Reference |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | Genome Instability, Mutation & Perturbation | Genome Instability | PIM1 kinase, a serine/threonine kinase that is overexpressed in human prostate cancer, promotes genomic instability in prostate cancer and there by mediates multiple roles in prostate tumorigenesis. | Reference |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | Serine/Threonine Kinase | Genome Instability, Mutation & Perturbation | Genome Instability | PIM1, which is overexpressed in advanced human prostate cancer, mediates genomic instability in prostate cancer through promoting polyploidy and multinucleation. | Reference |