| 15-LOX2 | Arachidonate 15-lipoxygenase, type B | Enzyme | Enabling Replicative Immortality | Senescence Downmodulation | 15-Lipoxygenase-2 (15-LOX2), a human-specific lipid-peroxidizing enzyme which is completely lost during prostate cancer progression, plays a key role in the induction of cellular senescence program. | Reference |
| 15-LOX2 | Arachidonate 15-lipoxygenase, type B | Enzyme | Insensitivity to Anti-Growth Signal | Tumor Suppression | 15-Lipoxygenase-2 (15-LOX2), a human-specific lipid-peroxidizing enzyme which plays a key role in the induction of cellular senescence program, functions as a critical tumour suppressor and is completely lost during prostate cancer progression. | Reference |