| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|---|---|---|---|---|---|
| ACK1 | Tyrosine kinase, non-receptor, 2 | Tyrosine Kinase | Castration Resistance | Castration Resistance | ACK1, a growth factor regulated tyrosine kinase, plays a crucial role in the modulation of radiation resistance in castration resistant prostate cancer through ACK1/AR/ATM signaling pathway. | Reference |
| ACK1 | Tyrosine kinase, non-receptor, 2 | Tyrosine Kinase | Androgen Receptor Signalling | AR Signaling | ACK1, a growth factor regulated tyrosine kinase, phosphorylates androgen receptor (AR), which up-regulates the expression of ATM (a critical regulator of the DNA damage checkpoint response pathways) and there by promotes radiation resistance in castration resistant prostate cancer (CRPC) | Reference |