| Protein | Protein Name | Molecular Type | Hallmark | Feature | Evidence | Reference |
|---|---|---|---|---|---|---|
| CHEK2 | Checkpoint kinase 2 | Serine/Threonine Kinase | Self-Sufficiency in Growth Signal | Cell Growth | Checkpoint kinase 2 (CHK2), a critical negative growth regulator which is lost during prostate cancer progression to castration resistance, plays a very significant role in prostate cancer cell growth. | Reference |
| CHEK2 | Checkpoint kinase 2 | Serine/Threonine Kinase | Genome Instability, Mutation & Perturbation | Mutation | Checkpoint kinase 2 (CHK2), a critical negative growth regulator which plays a significant role in prostate cancer cell growth is inactivated through a frame-shift mutation (1100delC) that abrogates its kinase activity. | Reference |