Human Prostrate Cancer Hallmarks Map

Comprehensive Map of Human Prostrate Cancer Associated Hallmarks

Here Human Prostate Cancer Hallmarks Map (HPCM) aims to represent a comprehensive view of human prostate cancer associated ten classic hallmarks (underlined) and three prostate cancer unique hallmarks (shown in red). Hallmark underlying cell biological and pathophenomic processes are indicated by white round rectangle and other important contributing factors are given as pale yellow rectangle. This integrated view includes crucial major cell signaling cascades, other important signaling molecules, oncogenes (which are over expressed during prostate tumorigenesis and shown in green), tumor suppressors (which are inactivated during prostate cancer progression and shown in red), adaptor protein (which provides a scaffolding role and shown in orange) and signaling modulators in the corresponding context (corresponding modulation is shown in pink dotted lines)