| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | c-MYC located at 8q24 is overexpressed during prostate cancer development. | Reference |
| MYC | V-myc avian myelocytomatosis viral oncogene homolog | Transcription Factor | Nuclear MYC protein overexpression is an early alteration in human prostatecarcinogenesis. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Leupaxin(LPXN) mRNA is overexpressed in human prostate cancer and expression intensities strongly correlates with gleason score. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | STAT3 gene is overexpressed in human prostate cancer. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | SMAD3 is overexpressed in human prostate cancer and its expression correlates with gleason score. | Reference |
| PABPC1 | Poly(A) binding protein, cytoplasmic 1 | RNA Binding Protein | PABPC1 located at 8q22.3 is overexpressed in prostate cancer. | Reference |
| IMP3 | Insulin-like growth factor 2 mRNA binding protein 3 | Translation Regulatory Protein | Oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in human prostate cancer and correlates with Gleasons score | Reference |
| SOCS3 | Suppressor of cytokine signaling 3 | Adaptor Protein | SOCS3 is overexpressed in castration resistant prostate tumour | Reference |
| DVL1 | Dishevelled segment polarity protein 1 | Adaptor Protein | DVL1 is overexpressed in prostate cancer and possibly related to prostate cancer progression by Wnt/beta catenine pathway | Reference |
| FHL2 | Four and a half LIM domains 2 | Adaptor Protein | FHL2 is overexpressed in prostate cancer | Reference |
| DAXX | Death-domain associated protein | Adaptor Protein | DAXX is frequently overexpressed in prostate cancer | Reference |
| BCL2L1 | BCL2-like 1 | Adaptor Protein | BCL2L1 is overexpressed and contributes to androgen resistance in prostate cancer | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | IGF1R is overexppressed in human prostate cancer. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | EGFR is overexpressed in prostatetumour and in prostate cancer cell line DU145. | Reference |
| RET | Ret proto-oncogene | Receptor Tyrosine Kinase | RET is overexpressed in histopathologically advanced prostatic intraepithelial neoplasia (PIN). | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | FGFR1 is overexpressed in advanced prostate cancer. | Reference |
| MET | Met proto-oncogene | Receptor Tyrosine Kinase | c-MET is overexpressed in human prostate cancer and is associated with dedifferentiation of prostate adenocarcinoma. | Reference |
| ERBB2 | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Receptor Tyrosine Kinase | HER-2/neu(ERBB2) is overexpressed in androgen independent prostate cancer and is linked with tumour stage and Gleason score. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | EPHA2 is overexpressed in prostate cancer. | Reference |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | G protein Coupled Receptor | CXCR4 overexpression is associated with prostate tumorigenesis | Reference |
| VAV3 | Vav 3 guanine nucleotide exchange factor | Guanine Nucleotide Exchange Factor | VAV3 is overexpressed in androgen-independent prostate cancer. | Reference |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | Guanine Nucleotide Exchange Factor | TIAM1 is overexpressed in prostate cancer and its expression is corelated with disase aggressiveness. | Reference |
| GOLM1 | Golgi membrane protein 1 | Transport/Cargo Protein | Golgi membrane protein 1 (GOLM1) is overexpressed in human prostate cancer tissue. | Reference |
| PRKCE | Protein kinase C, epsilon | Serine/Threonine Kinase | PRKCE is overexpressed in human prostate cancer. | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Polo-like kinase 1 (PLK1) is overexpressed during prostate cancer development and asociated with higher tumour grade. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | FYN is overexpressed during prostate cancer progression. | Reference |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | Membrane transport protein | ATP2A2(SERCA2) is overexpressed in PC3 prostate cancer cell line. | Reference |
| PIAS1 | Protein inhibitor of activated STAT, 1 | Cell Cycle Control Protein | PIAS1, a cytokine signaling modulator and cell cycle regulator which is overexpressed in local and metastatic prostate cancer cell and mediates docetaxel resistant prostate cancer cell survival. | Reference |
| AQP5 | Aquaporin 5 | Water Channel | Aquaporin 5 (AQP5) is overexpressed in human prostate cancer and plays a role in prostate cancer cell growth and metastasis. | Reference |
| MED15 | Mediator complex subunit 15 | Transcription Regulatory Protein | MED15 is overexpressed in metastatic castration resistant prostate cancer and enhances both androgen dependent and independent prostate cancer cell proliferation. | Reference |