DengueDT-DB DrugTagrget 1...

Drug Target 1
Database Id : DDTB001
Target Name	Genome Polyprotein - Dengue virus group Dengue virus type 2
GenBank ID Protein	323655	SwissProt ID	POLG_DEN2P (P12823)
Target Gene Name
Gene Sequence	View	GenBank ID Gene	M19197
Synonyms	Genome polyprotein Capsid protein C Core protein Envelope protein M Matrix protein Major envelope protein E Nonstructural protein 1 NS1 Nonstructural protein 2A NS2A Flavivirin protease NS2B regulatory subunit Flavivirin protease NS3 catalytic subunit EC 3.4.21.91 Nonstructural protein 4A NS4A Nonstructural protein 4B NS4B RNA-directed RNA polymerase EC 2.7.7.48 NS5
Protein Sequence	View	Number of Residues	295
Molecular Weight	33098 g/mol	Theoretical pI	9.13
Function	RNA helicase activity transferase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity RNA-directed RNA polymerase activity peptidase activity serine-type peptidase activity endopeptidase activity serine-type endopeptidase activity RNA binding double-stranded RNA binding structural molecule activity nucleic acid binding hydrolase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides pyrophosphatase activity nucleoside-triphosphatase activity ATPase activity catalytic activity ATPase activity, coupled helicase activity ATP-dependent helicase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding ATP binding
Process	viral genome replication viral life cycle viral infectious cycle	Component	viral envelope virion viral capsid
Specific Function	The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function. NS5 may play a role in the viral RNA replication. The NS2B/NS3 protease complex processes the viral polyprotein
Pathway map	map00230 Purine metabolism
Reaction	Selective hydrolysis of -Xaa-Xaa-\|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala
Pfam Domain Function	PF01003 Flavi_capsid PF02832 Flavi_glycop_C PF00869 Flavi_glycoprot PF01004 Flavi_M PF00948 Flavi_NS1 PF01005 Flavi_NS2A PF01002 Flavi_NS2B PF01350 Flavi_NS4A PF01349 Flavi_NS4B PF00972 Flavi_NS5 PF01570 Flavi_propep PF01728 FtsJ PF00949 Peptidase_S7
Transmembrane Regions	43-59 101-117 268-284 727-743 757-773
PDB file Link	1R6A	Download PDB File	1R6A
3D Structure Image	View	References	2827375 2741348