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Database Satistics
 
Drugs Targets : 13
Drugs : 4
Genes : 80
Attenuated Vaccine : 4
 
 


Drug Target 3
Database Id : DDTB003
Target Name Inosine-5'-Monophosphate Dehydrogenase 2 - Dengue virus group Dengue virus type 2
GenBank ID Protein 307066 SwissProt ID IMDH2_HUMAN (P12268)
Target Gene Name IMPDH2
Gene Sequence View GenBank ID Gene J04208
Synonyms
  1. Inosine-5'-monophosphate dehydrogenase 2
  2. EC 1.1.1.205
  3. IMP dehydrogenase 2
  4. IMPDH-II
  5. IMPD 2
Protein Sequence View Number of Residues 514
Molecular Weight 55806 g/mol Theoretical pI 6.90
Function
  1. catalytic activity
  2. oxidoreductase activity
  3. oxidoreductase activity, acting on CH-OH group of donors
  4. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
  5. IMP dehydrogenase activity
Process
  1. physiological process
  2. metabolism
  3. nucleobase, nucleoside, nucleotide and nucleic acid metabolism
    biosynthesis
  4. nucleotide metabolism
  5. ribonucleotide metabolism
  6. nucleoside monophosphate metabolism
  7. nucleotide biosynthesis
  8. purine nucleotide metabolism
  9. ribonucleoside monophosphate metabolism
  10. ribonucleotide biosynthesis
  11. purine ribonucleotide metabolism
  12. purine nucleoside monophosphate metabolism
  13. nucleoside monophosphate biosynthesis
  14. purine nucleotide biosynthesis
  15. purine ribonucleoside
  16. monophosphate metabolism
  17. ribonucleoside monophosphate
  18. biosynthesis
  19. purine ribonucleotide biosynthesis
  20. purine nucleoside monophosphate biosynthesis
  21. GMP metabolism
  22. purine ribonucleoside
  23. monophosphate biosynthesis
  24. GMP biosynthesis
Specific Function Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors
Pathway map map00230 Purine metabolism
Reaction inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+
Pfam Domain Function PF00571 CBS
PF00478 IMPDH
Transmembrane Regions
  • 73-92
  • 375-394
PDB file Link 1NF7 Download PDB File 1NF7
3D Structure Image View Chromosome Location Chromosome:3
SNPs References

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