The frame-based module of the Suiseki information extraction system Christian Blaschke CNB/CSIC The Suiseki system for the extraction of interactions from large collections of scientific text combines the statistical analysis of protein interactions, the analysis of the syntactical structure of the phrase, and a frame-based module dedicated to the detection of protein and gene names. The core of the system is the set of frames that capture the different modes in which the relation between proteins and genes are expressed in standard text. The approaches based on frames are considered as a valuable alternative in specialized fields such the one described here (Allen, 1995). We describe the details of the frames currently included in the system, their intrinsic value, coverage and performances. Even if at the detailed level the frame-based approach is able to capture only a fraction of the interactions contained in different sentences there exists a clear relation between the frequency of the detection of the interactions and the accuracy of the information obtained. To the extent that frequent interactions can be accurately detected with less than 20% error. Therefore, we propose that the use of pre-defined frames in combination with statistical and linguistical methods is a valid alternative for the analysis of interaction networks described in the molecular biology literature.