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    Opportunity: Manager/Director, Software Engineering @ Nodality -- South San Francisco, CA (US)
    Submitted by David Spellmeyer; posted on Wednesday, May 15, 2013


    Nodality is looking for an individual who is motivated to apply his/her expertise to lead software tool development in the high-impact area of personalized medicine. You will be part of a team that is working to make a difference in the lives of patients by advancing research and clinical biology to individualize medicine.

    Our proprietary Single Cell Network Profiling (SCNP) technology quantifies intracellular protein activity within individual cells in a high content and high throughput format. We have developed robust and reproducible assays that quantify intracellular network responses for systems biology research. We apply this technology to understanding diseases and new therapeutics, with the aim of developing highly predictive algorithms for patient stratification and therapeutic treatment selection. This approach interrogates cell signaling networks and pathways downstream of SNPs, gene and protein expression, providing an integrated, functionally relevant view of disease biology.

    Nodality offers a rich environment in which you will make key contributions to designing and building Nodality's software suite of tools used in generating, organizing and analyzing SCNP data. You will have the opportunity to work with, and learn from, world-class experts in a wide range of disciplines including, biology, computational sciences and translational medicine.

    Nodality's Lab Informatics platform includes tools used by biologists, clinical scientists, and laboratory specialists to manage reagents, patient samples, experimental setup, and data analysis. The platform uses a combination of Web technologies, including Django, and JavaScript/d3. Agile practices are used to develop software in close collaboration with end users using both in-house and off-shore resources with rapid release cycles. This platform has enabled increased efficiencies in all phases of generating data from experimental planning to execution and analysis. Your efforts will be key in enabling scientific discovery through improving the SCNP process and creating new capabilities in data analysis and interpretation.


    • Lead a small team of developers, including off shore consultants.
    • Set and coordinate software priorities through interfacing with users at Nodality and partner organizations.
    • Lead architecture definition, and development of related web components including front end, server-side, and system integration in collaboration with other team members.
    • Set direction for software development process methodologies including source control, unit testing coding standards and documentation.
    • Support all aspects of web based tool development from requirements gathering, implementation, testing, release, documentation and training for tools used in working laboratory environments, both in research and regulated environments.
    • Provide training, writing user documentation, database administration, and troubleshooting for applications deployed to a diverse user base.
    • Help shape the strategy for incorporating new technologies that will make a positive impact on the laboratory and analysis workflow.
    • Act as project manager and product owner, working with stakeholders to prioritize work, track and communicate progress against priorities.


    • A bachelor's or master's degree in computer science and/or related field
    • 7+ years of industrial experience with web platform development including Javascript, Python, Django.
    • Excellent verbal and written communication skills
    • Demonstrated ability to working with biomedical researchers and laboratory technologists.
    • Demonstrated willingness to be hands-on, pro-active and flexible
    • Demonstrated ability to work in multi-disciplinary environment
    • Demonstrated ability to design front ends that are optimized for the user workflow.
    • Experience using JQuery, HTML, XSLT, JavaScript Frameworks (e.g. Angular.js, Backbone.js, etc.)
    • Knowledge of one or more of these items is highly desirable: Hamilton Venus Software development, SharePoint integration, software development in a regulated environment and/or life sciences, with other programming languages
    • Understanding of relational database systems such as MySql, SQL Server.
    • Knowledge of multicolor flow cytometry a definite plus.
    • Programming experience in Windows and Linux environments.
    • Proficiency in Microsoft® Office tools.
    LOCALE:South San Francisco, CA


    We offer excellent career growth opportunities, and fully support promotion from within.

    Please submit your résumé or c.v. with a brief cover letter to jobs[at] Principals only.

    Nodality is an equal opportunity employer.

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