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    Opportunity: Lead Bio-informatician @ Sheffield Diagnostic Genetics Service -- Sheffield , UK
    Submitted by Darren Grafham; posted on Wednesday, May 22, 2013


    We are now recruiting to a new cross disciplinary Bionformatics Centre that will become the bedrock of research and high throughput data processing for the University and NHS Trusts ([...]atics). Sheffield Diagnostic Genetics Service (SDGS) is seeking to appoint a Lead bioinformatician. SDGS is an NHS regional Diagnostic Genetics laboratory providing a wide range of genetic specialist services to the public and private sectors with a number of key areas of service provision, including a full oncology service (, The Laboratory Services section provides analytical services to the 2 clinical sections (Oncology and Constitutional Genetics), oversees and contributes to research and development, and has a developing business in providing analytical services to Clinical Trials and research.

    SDGS is part of the Division of Pharmacy, Diagnostics and Genetics in Sheffield Children's NHS Foundation Trust and has an established record of integrated service development across the Pathology disciplines both within the Trust and with other Trusts in the region. The trust has invested in Next generation sequencing technologies (MiSeq and PGM) which are delivering data and looking to transform patient pathways. We are looking for the lead bioinformatician to perform alignment, primary data analysis, and optimisation of our analysis pipeline for both sequencing technologies and to continue to refine the process to aid the clinical scientists.


    You will have a range of experience of developing and implementing bioinformatics tools to assist data handling and processing of sequencing data ideally delivered in a highly regulated healthcare environment. You will have knowledge of next generation sequencing technologies and statistical techniques used in manipulation of data analysis and visualisation. You will have experience of integrating sequencing data with LIMS and other databases. You will have demonstrable programming skills in a range of languages. with proven experience in the development, management and delivery of genetic technologies particularly Next Generation Sequencing. You will have an excellent understanding of LIMs and IT. You will have demonstrable leadership and a collaborative approach but be self motivated and proactive in seeking resolutions to problems. You must be able to present and convey complex bioinformatics ideas in a scientific setting to a wide audience and facilitate their understanding.


    Permanent 37.5 hours per week


    Sheffield Children's NHS foundation trust and Sheffield bioinformatics centre


    GBP 30,764 to GBP 40,558 pa


    Please visit[...]04506

    For further details, please contact Mr D Grafham, Head of laboratory services on (0114) 2717005 or email darren.grafham[at]


    7th June 2013

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