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BACKGROUND

We are seeking an ambitious and self-motivated scientist interested in using transcriptomics to better understand individual cell types in the mouse brain. This post (one of two) has been funded by the EU as the initial 2.5 year ramp-up phase of the Human Brain Project (HBP; http://www.humanbrainproject.eu/en_GB). The overall goal of the HBP is to better understand the human brain and its diseases and ultimately to emulate its computational capabilities. Our part of this EUR 1 billion project is to start with the mouse, and to characterize the single cell-type transcriptomes of its different types of cell, such as different pyramidal cells in layers 2-5 of the neocortex. Transcriptome sequencing of single cells will take advantage of the expertise of the Sanger Institute-EBI Single Cell Genomics Centre where Prof Ponting already has group members.

RESPONSIBILITIES

You will report to Prof Ponting and will also work closely with other post-doctoral scientists, graduate students and laboratory support staff in the Ponting and Oliver groups, both in Oxford and at the WT Sanger Institute. You will be responsible for the management and analysis of a large number of transcriptome (short read sequencing) data sets, and for engaging with others in the HBP. You will liaise with a second postdoctoral worker who will focus on the isolation of populations of single cell types.

Interaction with other members of the Unit and University Department will be encouraged and as necessary there may be a need to establish working relationships with collaborators in other MRC Units or parts of the University Medical Sciences Division.

REQUIREMENTS

PhD / DPhil in biology, medical biology, medicine or a field relevant to computational genomics
Strong interest in genome research.
Excellent interpersonal skills, able to work independently and within a team.
Excellent communication skills, both oral and written.
Good working knowledge of office software.
Excellent organisational skills – managing both time and records effectively.
Numerate, and able to use own initiative to solve problems.
Able to script/program
Highly proficient in computational approaches that analyse and interpret next generation sequence data.
Skilled in the application of statistical approaches to biological problems.

PREFERENCES

Good publication track record and experience of presenting work at meetings.
Genetics/genomics and biomedical experience.
Experience of being a key participant in cross-disciplinary collaborations.
Evidence of multi-tasking and working to deadlines.
Experience of RNA biology or transcriptomics
Willingness to work with data from animal models
Previous experience of supervising research support staff/students
Accustomed to planning experiments, capturing data and meeting reporting deadlines

TERMS

This 2.5 year, fixed term position is available from 1st October 2013.

LOCALE

The MRC Functional Genomics Unit (FGU) at the University of Oxford is a strategic alliance between the MRC and the University of Oxford. The FGU is embedded within the Department of Physiology, Anatomy and Genetics and, from 1 July 2013 became a fully integrated University Unit.

The FGU is a world-renowned centre for comparative genomics and research into neuromuscular and neurodegenerative disorders. Its research combines the power of computational analyses and the latest experimental technologies in model organisms to reveal the roles of genes and genomes in health and disease. The Unit then pursues the translation of these discoveries into improved healthcare products and patient treatments via partnerships with clinicians as well as the pharmaceutical and biotechnology Industries.

The FGU offers excellent computational and laboratory facilities in the modern Henry Wellcome Building of Gene Function in central Oxford. Additional information about the Unit can be found at http://www.mrcfgu.ox.ac.uk and at http://www.dpag.ox.ac.uk/research/functional-genomics-1.

COMPENSATION

Fixed term post on Grade 7: GBP 29,541 to GBP 36,298, with a discretionary range to GBP 38,522 p.a.

HOW TO APPLY

Applications must be made online. For further details and to apply, please visit: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=109885 .

DEADLINE

The closing date for applications is 12 Midday GMT on Thursday 24th October 2013.

Interview date: Tuesday 12th or Wednesday 13th November 2013.

Discussion forums: Opportunity: Neurotranscriptomics: Postdoctoral RA (#109885) @ MRC Functional Genomics Unit at the University of Oxford -- Oxford, UK

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