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    Opportunity: Computational Biologist Postdoctoral Fellow (JBEI) (#76674) @ Lawrence Berkeley National Laboratory -- Berkeley, CA (US)
    Submitted by Jeff Todd; posted on Wednesday, December 11, 2013



    This position will be part of the Host Engineering group led by Aindrila Mukhopadhyay and part of the Fuels Synthesis Division at JBEI. Specifically the candidate will be involved in two sub-projects: (1) studying transport (and other tolerance) systems that play a role in alleviating fuel toxic response in microbial fuel production platforms and increase fuel export; and (2) Optimize the performance and regulation of the transporter/ tolerance gene.


    • Obtain candidate transporter/ tolerance genes from native hosts, strain banks or gene synthesis, for a variety of fuel candidates, and express in microbial hosts (primarily E. coli). Test resultant strains for effect on fuel production or alleviation of growth stress.
    • Survey microarray, RNAseg and other genomic data available in the literature or acquired at JBEI for cellular response to toxic effects of fuel production of metabolic engineering stress. Use this data to develop regulatable transcription systems that can be used for creating regulatable promoters in metabolic engineering.
    • Optimize the expression, function and regulation of the tolerance gene in fuel production hosts so as to increase specific production of fuel. Strategies such as directed evolution may be adopted.
    • Prepare manuscripts for publication and assist with the development of funding proposals and patents.
    • Participate in group meetings and seminars.
    • Maintain an accurate and detailed scientific logbook of all experiments performed. Ensure that others could duplicate results.


    • Recent PH.D in Microbiology, Chemistry, Biochemistry, Molecular Biology or related areas.
    • Expert knowledge in handling model microbes such as E. coli and other bacteria including growth, culturing, transformation, gene manipulation, creation of expression systems and protein purification.
    • Experience with working with microbial transport systems, microbial regulatory mechanisms and stress response.
    • Ability to work with guidance of a director or principal investigator and collaborators and well as to conduct experiments independently, maintain appropriate records and manage data.
    • Strong verbal and written communication skills with ability to write grant proposals and establish independent funding.


    • Experience with scientific journal writing submissions and ability to write above average reviews and articles for submission.
    • Experience with handling different types of omics data such as that from microarray analysis, RNAseq or metagenomic sequences.


    This is a 1-year term appointment with the possibility of renewal for up to 5 years based upon satisfactory job performance, continuing availability of funds, and ongoing operational needs.


    Berkeley, CA


    Salary for post-doctoral positions depends on years of experience post-degree.


    For full consideration, follow the link to the job posting and apply directly to Berkeley Lab. As part of the online application process, please complete a profile, including uploading attachments relevant to the opportunity. Be sure to reference where you found the position (Bioinformatics.Org).[...]76674


    Berkeley Lab is an affirmative action/equal opportunity employer committed to the development of a diverse workforce.

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