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BACKGROUND

The VIB Center for the Biology of Disease and KU Leuven Center for Human Genetics has a position for a highly motivated postdoctoral fellow with expertise in cancer bioinformatics.

Research project:
We recently discovered domatic mutations in CNOT3 in T-cell acute lymphoblastic leukemia (De Keersmaecker et al. Nature Genetics 2013). CNOT3 encodes a protein that is implicated in RNA transcription and also in RNA degradation. In an ERC-funded project, we aim to study the role of impaired RNA degradation and its effect on transcriptional networks in leukemia cells.

Selected references to previous work:

Kalender et al. Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia. PLoS Genet.2013 Dec;9(12):e1003997,
De Keersmaecker K, et al. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature Genetics, 2013;45:186-190.

REQUIREMENTS

Your profile:

You have a PhD in the Life Sciences, Engineering, Bioinformatics, Computational Science or equivalent.
You have a good knowledge of cellular biology and genetics.
You are fluent in English.
You have a strong publication record.
You have solid experience with bioinformatics programming and statistics for bioinformatics, including Linux, scripting (e.g. Python, Perl, Bash), R incl. Bioconductor), Java, Galaxy, UCSC Genome Browser, Ensembl API, etc.
Experience with the analysis of next-generation sequence date is a plus: exome sequencing, SNP/indel calling, Structural variation, RNA-seq, etc.

TERMS

Starting date: March-April 2014.
We offer a 2 year contract subject to renewal.

LOCALE

The successful applicant will work in the Laboratory of Prof. Jan Cools, at the VIB and KU Leuven (University of Leuven, Belgium). You will interact with Phd students and postdocs in our bioinformatics interest community (http://med.kuleuven.be/big), especially with the group of Prof. Stein Aerts. You will be hosted in VIB, an international top research institute in the center of Europe.

FOR MORE INFORMATION

http://gbiomed.kuleuven.be/mbl
http://www.vib.be/en/research/scientists/pages/jan-cools-lab.aspx
http://med.kuleuven.be/big
http://www.kuleuven.be/symbiosys/

HOW TO APPLY

Please send your CV, motivation letter and contact information for three references to Jan Cools (jan.cools[at]cme.vib-kuleuven.be).

Discussion forums: Opportunity: Postdoc position -- cancer bioinformatics @ KU Leuven Center for Human Genetics -- Leuven, Belgium

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