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    Opportunity: Senior Bioinformatician -- Mouse Genomes Project @ Wellcome Trust Sanger Institute -- Hinxton/Cambridge, UK
    Submitted by Sam Bowker; posted on Friday, March 28, 2014


    We are seeking an outstanding Senior Bioinformatician to contribute to the building of a medically important set of mouse genome sequences and contribute to the comparative analysis as part of the Mouse Genomes Project ([...]omes/).

    The Mouse Genomes Project is an ongoing effort to sequence the genomes of the common laboratory mouse strains, cataloging all forms of molecular variation, and to produce genome sequences of each strain. Phase 1 (2008-2011) of the project involved deep sequencing of the strains and creating comprehensive catalogs of molecular variation ranging from single base changes up to large structural differences of multiple kilobases (1, 2). We are now in phase 2 (2012 onwards) of the project with the focus being the production of accurate genome sequences, strain specific gene annotation, and comparative analysis of the strains.

    This postholder will be required to analyse across large volumes of sequencing data to contribute to answering specific scientific questions. You will also contribute to regular data releases, investigate and compare new tools in production of genome assemblies and explore the use of 3rd generation sequencing technologies for improving the quality of the genomes and variant identification.

    This role would suit somebody with some previous bioinformatics experience or a newly qualified graduate student who wishes to gain direct knowledge of next-generation sequencing technologies and analysis. The successful candidate will work closely with established team of analysts and developers so previous experience with next-generation sequencing data is not strictly necessary.


    • Demonstrable record in bioinformatics
    • Advanced degree (e.g. PhD) or equivalent research experience
    • Demonstrable record of computational data analysis
    • Excellent communication skills (written and verbal)
    • Proficiency in one or more scripting languages


    • Familiar with working on the unix command line
    • NGS data analysis
    • Knowledge of genome assembly
    • Experience in comparative genomics


    Positions are available on a permanent and fixed-term basis. Please indicate if you would not like to be considered for a fixed-term position on your application.

    Apply on line submitting a CV and covering letter at[...]80647

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