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EXCERPT

Bowhead whales have not only been estimated to live over 200 years, making this the longest-lived mammal, but these animals also exhibit very low disease incidence until much more advanced ages than humans. The mechanisms for the longevity and resistance to aging-related diseases of bowhead whales are unknown, but it is clear they must possess aging prevention mechanisms. In particular in context of cancer, bowhead whales must have anti-tumour mechanisms, because given their large size and longevity, their cells must have a massively lower chance of developing into cancer when compared to human cells. As such, our goal by sequencing the genome of the bowhead whale is to help identify longevity assurance mechanisms and to provide a resource that other scientists can use to study this extraordinary species.

AVAILABILITY

http://www.bowhead-whale.org

ARTICLE

Keane M, Semeiks J, Webb AE, Li YI, Quesada V, Craig T, Madsen LB, van Dam S, Brawand D, Marques PI, Michalak P, Kang L, Bhak J, Yim HS, Grishin NV, Nielsen NH, Heide-Jorgensen MP, Oziolor EM, Matson CW, Church GM, Stuart GW, Patton JC, George JC, Suydam R, Larsen K, Lopez-Otin C, O'Connell MJ, Bickham JW, Thomsen B, de Magalhaes JP (in press) "Insights into the evolution of longevity from the bowhead whale genome". Cell Reports DOI: 10.1016/j.celrep.2014.12.008

Discussion forums: Resources: The Bowhead Whale Genome Resource

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