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BACKGROUND

The Cai lab is pioneering the area of large-scale DNA design and engineering. We are working on the largest synthetic chromosome to be made in the UK as a part of the Sc2.0 Project [http://www.syntheticyeast.org]. We also collaborate with the Edinburgh Genome Foundry (founded and co-directed by Dr. Cai), which was awarded GBP 5.5M from BBSRC to build a highly automated DNA assembly platform capable of producing up to chromosome-size DNA molecules at the University of Edinburgh. The assembly of large DNA constructs has many applications in genome engineering and phenotype-genotype interactions mapping, e.g. through chromosome scrambling [Dymond et al., Nature 2011; Annaluru et al., Science 2014; Shen et al., Genome Research 2016].

RESPONSIBILITIES

1. Developing novel computational methods to design and assemble large scale DNA sequences (30%)
2. Developing computational methods to support large scale DNA synthesis and assembly automation (30%)
3. Supervising/training and advising visiting research staff and postgraduate staff/students undertaking project work in the laboratory (10 %)
4. Analysis of data for publication in international journals (20%)
5. Presenting and critiquing data at regular group and departmental meetings (5%)
6. Assist the PI preparing grant proposals (5%)

REQUIREMENTS

Essential:

A PhD (or shortly obtain a PhD) in Computational Biology, Bioinformatics, Process Engineering, Computer Science, or another relevant field.
Excellent knowledge of scientific computing using such as Python, R, Matlab, C++.
Proficient in bioinformatics algorithms
Understands the workflow of DNA synthesis and assembly

PREFERENCES

Software development skills (web development, git).
Familiarity with DNA assembling methods (Gibson Assembly, Golden Gate).
Experience with High Performance Computing projects.
Excellent communication skills

COMPENSATION

GBP 31,656 - GBP 37,768 per annum

HOW TO APPLY

Applications are open until April 20, 2016 at the following address:

http://bit.ly/21O3TFm

Please provide a CV and a cover letter.

Discussion forums: Opportunity: Postdoctoral Research Fellow in computational and synthetic biology @ University of Edinburgh, UK

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