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BACKGROUND

Are you ready to develop and apply cutting-edge single cell analytical tools? Interested in solving the enigmas of thymic epithelial cell biology?

We are looking for an enthusiastic, highly motivated Postdoctoral Fellows who will develop their career by contributing to our study and joining a team of internationally renowned researchers at the Sanger-EBI Single Cell Genomics Centre, investigating the fascinating properties of thymic epithelial cells (TEC).

TEC are unique because they express almost the complete set of protein-coding genes. Single cell approaches are only now able to answer important questions central to a molecular understanding of this promiscuous gene expression (PGE) in TEC. The planned research programme will use unbiased genome-wide transcriptome and epigenome, and selected protein expression analyses at single cell resolution to map intracellular and population-wide expression landscapes. This project is funded by a Wellcome Trust Strategic Award ("The Homunculus in our Thymus: A Cellular Genomics Approach", PIs G. Holländer and C. Ponting).

The candidate will be a highly talented postdoctoral fellow with strong statistical and/or analytical skills. Excellent knowledge of current issues in single cell data generation and analysis along with understanding of statistical theory are highly desirable.

This position offers scope for applying these methods to questions directly relevant to TEC biology as well as the development of new single cell transcriptomic analytical approaches.

Other Information:
As a world leader in human genomics, genome informatics, and whole genome DNA sequencing, the Wellcome Trust Sanger Institute (WTSI) is now focusing large-scale genotyping, DNA sequencing, and mathematical analysis on illuminating the biology of different cell types.

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The post is a three year fixed-term contract.

REQUIREMENTS

A PhD in Genomics, Genetics, Computational Biology (or similar), and a passion for problem solving
An understanding, experience and published outcomes from analysing and interpreting large datasets using at least one statistical package (e.g. R/SPLUS, SAS) and experience in programming (e.g. Perl, Python, C++, Java)
Excellent written and spoken English are essential and the ability to effectively communicate with collaborators and occasionally present oral communication to large groups
Proven independent working style, technical problem solving, data analysis and generation of novel ideas

PREFERENCES

Extensive programming experience and computational analysis of next generation sequence data
Good experience with (single-cell) DNA- and RNA-seq analytical approaches
Appreciation of current bioinformatics/computational approaches
Experience in supervising and training other laboratory personnel in specialized techniques and presenting results at scientific conferences (posters and talks)
Training in statistical methods appropriate for biological research and experience in genomics approaches and in method development would be advantageous.

COMPENSATION

PDF Salary range: GBP 30655 to GBP 38428 per annum plus excellent benefits.

Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

TERMS

Fixed-term for 3 years

ABOUT US

The Sanger Institute is a charitably funded research centre that applies the power of genomics to uncover the basis of genetic and infectious disease. We conduct science at a scale and speed that sets our research apart. Our passion is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

HOW TO APPLY

Please visit https://jobs.sanger.ac.uk/wd/plsql/wd_portal.show_job?p_web_site_id=1764&p_web_page_id=258504

Please include a covering letter and CV with your application.

Discussion forums: Opportunity: Postdoctoral Fellow -- Computational Biology @ Wellcome Trust Sanger Institute -- Hinxton/Cambridge, UK

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