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Opportunity: Scientist, Bioinformatics (#6284BR) @ Regeneron Pharmaceuticals -- Tarrytown, NY (US)
Submitted by Yushen Chang; posted on Monday, April 25, 2016
BACKGROUND
The Molecular Profiling group is looking for a Scientist to analyze immuno-oncology (I/O) clinical, preclinical, and public profiling data to support I/O target mechanism studies, biomarker and target discovery & development, as well as implement and develop I/O data analysis pipeline using cutting-edge algorithms and statistically sound methodologies.
RESPONSIBILITIES
- Collaborate with immuno-Oncology (I/O) scientists in preclinical and clinical departments to design profiling experiments and draft data analysis plan
- Communicate results with I/O scientists, refine analysis based on feedback, and plan/prioritize follow-up experiments
- Prepare clear, concise and easy-to-understand presentations and documentations for collaborators, senior management and government agencies
- Analyze proprietary and public profiling data to support I/O targets and biomarker discovery
- Analyze proprietary tox profiling data to support Tox studies
- Analyze proprietary clinical profiling data to support Clinical studies
- Contribute to team effort of developing I/O data analysis strategies and establishing I/O data analysis best practices
- Participate in team effort of organizing and integrating proprietary and public molecular profiling data to enable data sharing and visualization for bench scientists
REQUIREMENTS
This position requires a minimum of a PhD in a related field, and preferably 2+ years postdoctoral experience. Additional requirements include, but are not limited to:
- Expertise in immuno-oncology
- Expertise in NGS data analysis to detect gene expression, variants, copy number variation, fusion and alternative splicing
- Strong preference for R power users, especially DeSeq 6+
- Strong preference for experience in Single Cell Sequencing
- Experience with analyzing cancer profiling data in the public domain such as TCGA
- Experience with a variety of molecular profiling platforms such as microarray and NGS, and their data analysis best practices
- Familiarity with TCR repertoire sequence analysis, antigen prediction, modeling (e.g., machine learning) and network building (e.g. gene regulation networks): Keen interest and determination to be at the cutting-edge of algorithms and model building
- Familiarity with bioinformatics tools and software such as R/Matlab, Linux, Perl, Python, Ruby, Java, Ruby on Rails, SQL, web programming
PREFERENCES
PhD with 2+ years postdoctoral experience analyzing TCR repertoire.
TERMS
Regular, full Time position eligible for employee benefits.
LOCALE
Tarrytown, New York.
COMPENSATION
Commensurate to experience.
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