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Nature: Initial sequencing and analysis of the human genome
Submitted by Gary Van Domselaar; posted on Tuesday, February 13, 2001 (3 comments)
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The much-anticipated Nature publication from International Human Genome Sequencing Consortium has been released. Here's an excerpt:
"The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence."
"The rediscovery of Mendel's laws of heredity in the opening weeks of the 20th century [1-3] sparked a scientific quest to understand the nature and content of genetic information that has propelled biology for the last hundred years. The scientific progress made falls naturally into four main phases, corresponding roughly to the four quarters of the century. The first established the cellular basis of heredity: the chromosomes. The second defined the molecular basis of heredity: the DNA double helix. The third unlocked the informational basis of heredity, with the discovery of the biological mechanism by which cells read the information contained in genes and with the invention of the recombinant DNA technologies of cloning and sequencing by which scientists can do the same."
"The last quarter of a century has been marked by a relentless drive to decipher first genes and then entire genomes, spawning the field of genomics. The fruits of this work already include the genome sequences of 599 viruses and viroids, 205 naturally occurring plasmids, 185 organelles, 31 eubacteria, seven archaea, one fungus, two animals and one plant."
"Here we report the results of a collaboration involving 20 groups from the United States, the United Kingdom, Japan, France, Germany and China to produce a draft sequence of the human genome. The draft genome sequence was generated from a physical map covering more than 96% of the euchromatic part of the human genome and, together with additional sequence in public databases, it covers about 94% of the human genome. The sequence was produced over a relatively short period, with coverage rising from about 10% to more than 90% over roughly fifteen months. The sequence data have been made available without restriction and updated daily throughout the project. The task ahead is to produce a finished sequence, by closing all gaps and resolving all ambiguities. Already about one billion bases are in final form and the task of bringing the vast majority of the sequence to this standard is now straightforward and should proceed rapidly."
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Expanded view | Monitor forum | Save place
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Dear Gentleman,
metalife knowledgebase offers the user a ?single entry point? for research and analysis of available decentralized allocated data. metalife knowledgebase also increasingly integrates data that have been generated by means of own newly developed tools. for instance, by means of the text extraction tools and based on the metalife tmp (tmp = text minding process), data can be derived immediately from scientific publications and used for supplementation of annotations to protein entries or addition of new classes of information to the metalife knowledgebase. the metalife knowledgebase is based on standard components ( pc, sql server 2000). it contains the majority of public accessible molecular biological data as well as indices to the primary data collections, serves as a central in-/output memory for the metalife tools and applications, saves information and knowledge references that are created by highly developed metalife technologies, allows the easy integration of proprietary data and applications, compatible with internet technology. the metalife knowledgebase forms the fundament of our progressive bio-informatics package.
best regards
your Metateam
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Dear Gentleman,
Metalife finder offers, as an alternative to the user interface of metalife explorer, a classic search method. The tool is designed for those users who would purposefully like to access separate primaty data collections. By integrating the metalife working environment, an interface was created to all other applications.
The most important product features are:
? parser based user interface
? classic access to separate data collections
? based on the metalife knowledgebase
? possible inquiries about multiple databases and data categories
? integrated in the metalife working environment
best regards,
your metateam
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Dear Gentleman,
In april 2002 the metalife team released the first version of the metalife explorer.
with metalife explorer the next central metalife tool is implemented in a first version. It enables the user to access the content of metalife knowledgebase thoroughly. All integrated data sources are exploited with one query. Simple queries as well as advanced queries are possible. The user does not need to know the internal data structures of the different data sources. Cross database queries are possible. A compact yet comprehensive dossier about a gene or a protein can be obtained with a single query. Data obtained from
structured databases stand in line with text extracted data. Among others, information of the dossiers includes sequences, pathways, publications, patents and relation to diseases. metalife explorer serves as a core part of the metalife working environment.
best regards
your Metateam
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