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    Opportunity: COMPUTATIONAL BIOLOGIST, RNAi Platform (#503) @ Broad Institute--Cambridge, MA (US)
    Submitted by Laura Bonfitto; posted on Tuesday, March 08, 2011


    COMPUTATIONAL BIOLOGIST, Broad Institute-The RNAi Consortium (TRC), RNAi Platform and Cancer Program, to create and implement novel algorithms for functional genomics analysis based on the biological effect of suppressing genes through RNA interference (RNAi) and other perturbations. The RNAi Platform and Broad Cancer Program have collaborated to generate large-scale and unique datasets measuring the effects of RNAi reagents in diverse cancer types. These data can serve as the basis for computational investigation into functional genomics, regulatory networks and pathway analyses. Examples of research areas include new methods to understand the phenotypic data collected from RNAi screens at the level of networks and pathways, integrating functional and structural genomic datasets, and computationally modeling the effects of on- and off-target knockdown of genes. These and related questions will be pursued in collaboration with scientists and computational biologists in the RNAi Platform and the Cancer Program. Position offers the unique opportunity to apply cutting-edge computational approaches to biological and biomedical research on a scale and depth not available in any other setting.


    • Advanced degree in computational biology, physical science, applied mathematics or demonstrable equivalent research experience and experience modeling large-scale data sets.
    • Proficiency with Python, Jython, Java, relational databases, SQL, statistics tools such as MATLAB or R desired.
    • Should possess excellent communication skills and the ability to work effectively in a fast-paced environment.


    The Broad Institute was launched to pioneer a new model of collaborative biomedical science that would transform medicine. To accomplish these goals, we have built an amazing team of talented Broadies who work together to realize this transformation.

    We are always looking for new Broadies to join our team and help us tackle important problems at the cutting edge of science.

    The Broad community includes professional scientists from many disciplines, administrative staff, and students. We seek to cultivate an interdisciplinary, goal-oriented work environment that unleashes scientific creativity and empowers our people to pursue ambitious and critical projects.

    Our work transcends traditional academic boundaries, giving Broad employees and affiliates access to an unparalleled biomedical research community across the Harvard and MIT communities and beyond.


    The Broad Institute is committed to providing its employees with a competitive compensation and benefits package. We recognize the need for our employees to have a balance between work and personal life. To that end, our benefit plans and options reflect our desire to promote an environment that supports the health, diversity, and general wellbeing of our employees.

    All Broadies also have access to world-class research and state of the art technology and are fully supported in their professional development, pushing the envelope for further growth.


    Please apply via our website:[...]enter. Position 503.


    The Broad Institute is an equal opportunity employer.

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