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    Opportunity: Postdoctoral Associate, Chemical Biology Program (#507) @ Broad Institute--Cambridge, MA (US)
    Submitted by Laura Bonfitto; posted on Saturday, April 09, 2011


    Joins the Learning from Human Genetics initiative aimed at integrating findings from human disease genetics with novel approaches in functional genomics and chemical biology to make progress toward treatments for Crohn's Disease and Type I Diabetes. As a member of the initiative, extensively interacts with the team of immunologists and molecular biologists that are performing functional genomics assays with the goal of identifying cellular pathways relevant to disease. As a member of the Chemical Biology Program, establishes and performs primary and secondary assays aimed at the development and optimization of small molecule probe compounds for disease-relevant pathways. Works together with the assay development and screening teams and closely collaborates with chemists to enable iterative rounds of compound testing and optimization.

    Characteristic Duties:
    • Responsible for the specification, implementation and validation of assays for high-throughput screening and secondary assays aiming at the development of chemical probes
    • Works with HTS, automation, informatics and chemistry staff at all levels to develop, implement, monitor and coordinate all processes
    • Works with informatics group to define requirements for capture of assay development protocols and assay data and establish an ELN environment
    • Works independently to design and execute research projects; plans, schedules, or coordinates the development of chemical probe compounds for targets of interest. Ensures that critical project requirements, timelines and deliverables are met
    • Performs detailed characterization of hits and chemically optimized compound using biochemistry and enzymology based on previously demonstrated success and technical proficiency in these areas
    • Determines the feasibility and makes recommendations regarding the acquisition and/or implementation of new technologies, reagents and assay procedures
    • Uses demonstrated scientific creativity, collaboration with others and independent thought to expand technical capabilities and identify new research opportunities
    • Regularly presents data at meetings, participates in external activities, and technical meetings
    Supervision Exercised:
    • Where appropriate, depending on the needs of the project, may supervise scientists, post-docs or technicians, provide major input to staffing of project teams, and mentor/train staff


    • Ph.D. in immunology, cell biology or biochemistry and at least 3 years relevant experience. Background in autoimmune or metabolic disorders strongly preferred
    • Solid experience in the development and utilization of biochemical assays and/or cell based assays
    • Experience working with primary cells and mouse disease models a plus
    • Strong publication record in high impact journals
    • Excellent communication skills and the ability to interact professionally with all levels of staff and with internal and external investigators in a fast paced environment required
    • Open mind to consider challenging assay formats, analysis and physiologically relevant cell models.
    • Excellent organization and time management skills required
    • Must be able to use sound judgment to handle a variety of tasks and to shift priorities simultaneously, as well as to effectively solve problems
    • Experience with high throughput and high content screening a plus
    • Basic knowledge of computer applications required, and experience with large data sets and analysis of HTS data a plus


    The Broad Institute was launched to pioneer a new model of collaborative biomedical science that would transform medicine. To accomplish these goals, we have built an amazing team of talented Broadies who work together to realize this transformation.

    We are always looking for new Broadies to join our team and help us tackle important problems at the cutting edge of science.

    The Broad community includes professional scientists from many disciplines, administrative staff, and students. We seek to cultivate an interdisciplinary, goal-oriented work environment that unleashes scientific creativity and empowers our people to pursue ambitious and critical projects.

    Our work transcends traditional academic boundaries, giving Broad employees and affiliates access to an unparalleled biomedical research community across the Harvard and MIT communities and beyond.

    The Broad Institute is committed to providing its employees with a competitive compensation and benefits package. We recognize the need for our employees to have a balance between work and personal life. To that end, our benefit plans and options reflect our desire to promote an environment that supports the health, diversity, and general wellbeing of our employees.

    All Broadies also have access to world-class research and state of the art technology and are fully supported in their professional development, pushing the envelope for further growth.


    Please apply via our website:[...]enter.


    Position 507


    The Broad Institute is an equal opportunity employer.

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