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Opportunity: Post-Doctoral Research Fellow (#SC-23764) or SAP II/III (#SC-23763) @ FHCRC--Seattle, WA (US)
Submitted by Alysha Duran; posted on Tuesday, June 21, 2011
BACKGROUND:
Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference!

RESPONSIBILITIES:
An investigator in the Computational Biology program at the FHCRC is recruiting a postdoctoral fellow to develop and apply computational and statistical algorithms. The lab has a strong focus on the adaptive immune system and clinical diagnostics. S/he will be expected to head a set of independent projects, taking the projects through to publication.

This research group is computationally based and focuses on the adaptive immune system and its response to viral infection, with autoimmune disease a particular area of interest. Taking advantage of new high-throughput sequencing technology, in collaboration with experimental groups, we are isolating and sequencing millions of t-cell receptor VDJ rearrangements from different clonotypes. With this new technology, we can attempt a comprehensive description of the t-cell repertoire and ask what how this repertoire is modified during an immune response.

Major Duties:
* Research on DNA sequencing technology to profile T-cells within the immune system.
* Developing diagnostics for Juvenile Diabetes and Multiple Sclerosis.
* Developing advanced DNA sequencing methods to catalogue unique B-cell DNA signatures corresponding to distinct pathogen exposures and disease states in humans.
* A study on immunosenesence - the deterioration with age of the human immune system.
* A study on the cellular immune response to an acute viral infection (such as yellow fever) using novel high-throughput sequencing technology to measure and track millions of T cells in parallel.

REQUIREMENTS:
A Ph.D. in physics, mathematics, computer science, biology, biostatistics, or a related field is required. A strong mathematics background and the ability to program in C, C++, or Java are essential. Recent or prospective graduates are encouraged to apply. For the programmer position, a PhD is not required.

TERMS:
Equal Employment Opportunity

LOCALE:
Seattle, WA

COMPENSATION:
Salary DOE + Excellent Benefits

HOW TO APPLY:
Please reference position SC-23763 or SC-23764 and send cover letter detailing your research interests, curriculum vitae, and three letters of reference to scanaver[at]fhcrc.org.

DEADLINE:
Open until filled

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