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    Opportunity: BIOINFORMATICIAN / Senior BIOINFORMATICIAN - ICGC Prostate Cancer (#81002) @ Wellcome Trust Sanger Institute--Hinxton/Cambridge, UK
    Submitted by Sam Bowker; posted on Thursday, October 13, 2011


    The Wellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health & disease.

    The Wellcome Trust Sanger Institute operates at the forefront of genomics, sequencing and analyses targeting a wide range of genomes from single cell pathogens to higher vertebrates, with an emphasis on genomes relevant to human medicine and welfare. The Cancer Genome Project at the Institute has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers ([...]nome/).


    Highly motivated Bioinformatician required to help analyse data from a large-scale sequencing study of Prostate Cancer.

    A Bioinformatics/Senior Bioinformatics position has become available within the Cancer Genome Project as part of the International Cancer Genome Consortium (ICGC) Prostate Cancer initiative. The project will involve the comprehensive analysis of coding mutations and gene rearrangements of 250 whole genome shotgun datasets. The systematic collection of these data will help identify the genes and genetic mechanisms involved in the genesis of this disease and will ultimately empower improved detection, prevention and treatment.

    The role involves working closely with scientific and IT staff on the project to ensure the efficient analysis of the data sets. Specifically, this will include developing IT systems to track the data, accurately call mutations from the samples, analyse the patterns of mutations across all samples and across other cancer types.


    The position would suit a Bioinformatician who enjoys applying their skills to analysing large biological data sets and finding novel ways to analyse and display such data. We are looking for an individual who enjoys working in multi-disciplinary team environment to help solve complex biological problems relating to cancer genetics.

    Essential Skills:
    • Good degree in Bioinformatics, Scientific Discipline or Computer Science
    • Software engineering skills (using Perl or Java)
    • ORACLE/MySQL databases
    • Enjoy working as part of a team


    Ideal Skills:
    • UNIX/LINUX development experience. C++, R, Web development, AJAX
    • Experience of handling Next Generation sequencing data
    • Background in cancer genetics
    Although experience of bioinformatics would be a distinct advantage, applications are welcome from enthusiastic and committed graduates who wish to pursue a career in bioinformatics whilst carrying out a challenging and rewarding role. Applicants with significant experience would be considered for appointment as a Senior Bioinformatician, while less experienced applicants would be considered for appointment at the lower grade as a Bioinformatician.


    This position is fixed-term for 2 years.


    Salary: GBP 21,115 - GBP 37,690 per annum dependent on experience

    Please state your current salary in the covering letter.

    The Institute has excellent purpose built facilities on the Genome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities. Further details can be found on our website,


    To submit your CV and apply for this job please go to, to register and apply on line.


    Closing Date: 29th October 2011

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