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    Opportunity: BIOINFORMATICS Analyst / Senior BIOINFORMATICS Analyst (#774) @ Broad Institute--Cambridge, MA (US)
    Submitted by Laura Bonfitto; posted on Thursday, June 21, 2012


    A central goal of cancer research is the development of methods to predict vulnerabilities of individual tumors based upon their molecular features. To this end, the Broad Institute is undertaking an interdisciplinary approach using genetic and chemical disruption of genes and pathways in hundreds of well-annotated model systems of cancer, and creating high-throughput datasets of tumor vulnerabilities. To enhance the seamless integration of data and analyses derived from different types of molecular perturbation, we are undertaking the computational challenge of merging these datasets into a central, easily accessible database.


    Overall Responsibilities:
    This individual will work to develop this database and associated Web-based tools that enable computational and experimental biologists to integrate and analyze data from various high-throughput biology projects, including small-molecule, RNAi, and genomic variation data in cancer-related cell lines. Specific work will focus on the development of an integrated data model and associated means to query the integrated data in a robust, easy to use and stable manner. We envision that a working database, object-relational mapping, and initial query tools will comprise the main work products for the first 12-18 months. An important goal for that term will be to provide for easy maintenance of the database by computational biologists in the future. An overarching responsibility of this individual will be to work closely members of the Cancer Program and Chemical Biology Program communities to help to set and execute a longer term vision for data integration at the interface of these disciplines.

    Characteristic Duties:
    • Develop and implement a finalized schema from an existing information model
    • Integrate data across formats and sources by robust synchronization with existing transactional systems
    • Work with researchers to specify, design, and implement database-driven Web applications that serve as a front-end to retrieval and analysis tools
    • Design and implement interfaces to back-end analysis tools
    • Enable computational scientists to build sophisticated queries and tools by creating materialized views and object-relational maps facilitating rapid prototyping of new analyses
    • Work with technical writers to document functionality


    • Bachelor's or Masters in Computer Science, Engineering, Statistics, Physics, or any quantitative discipline
    • Experience with at least one modern language (2+ desirable)
    • Expertise in server- and client-side web development required
    • Knowledge of relational databases (e.g. Oracle) and SQL required
    • Bioinformatics Analyst (3+ years experience) or Senior Bioinformatics Analyst (6+ years experience) with biological datasets and/or exposure to an analytic field such as bioinformatics, computational biology, machine learning, or statistics required
    • Application integration experience (e.g. web services, messaging) a plus
    • Data warehousing experience a plus
    • Familiarity with genomic databases or prior experience interacting with such databases helpful
    • Sensitivity to end-user needs, reflected in design of user interface and application workflow
    • Excellent written and verbal communications skills
    • Self-starter with excellent problem-solving, organizational, and people skills
    • Adaptable to rapidly-changing and high-demand environments


    Cambridge, MA


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