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Resources: miR-EdiTar: A database of predicted A-to-I edited miRNA target sites
Submitted by Francesco Russo; posted on Thursday, October 11, 2012
A-to-I RNA editing is an important mechanism which consists of the conversion of specific adenosines into inosines in RNA molecules. Its dysregulation has been associated to several human diseases including cancer. Recent work has demonstrated a role for A-to-I editing in microRNA (miRNA) mediated gene expression regulation. In fact, edited forms of mature miRNAs can target sets of genes that differ from the targets of their unedited forms. The specific deamination of mRNAs can generate novel binding sites in addition to potentially altering existing ones.

This work presents miR-EdiTar, a database of predicted A-to-I edited miRNA binding sites. The database contains predicted miRNA binding sites that could be affected by A-to-I editing and sites that could become miRNA binding sites as a result of A-to-I editing.

AVAILABILITY:
miR-EdiTar is freely available online at http://microrna.osumc.edu/mireditar

ARTICLE:
miR-EdiTar: A database of predicted A-to-I edited miRNA target sites
Alessandro Laganà, Alessio Paone, Dario Veneziano, Luciano Cascione, Pierluigi Gasparini, Stefania Carasi, Francesco Russo, Giovanni Nigita, Valentina Macca, Rosalba Giugno, Alfredo Pulvirenti, Dennis Shasha, Alfredo Ferro, Carlo M. Croce
Bioinformatics (2012); doi: 10.1093/bioinformatics/bts589

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