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BACKGROUND

Our laboratory focuses on the mechanisms controlling pluripotency and cell proliferation in fish midbrains through the study of an exceptional neural model, the optic tectum, which has separated populations of stem cells, slow and fast progenitors, cells exiting the cell cycle, and differentiating neurons. Developmental studies in zebrafish and medaka are combined with observations on juveniles and adults in physiological and regenerative conditions. Our laboratory is part of the CNRS center of Gif-sur-Yvette, close to the University campus of Orsay and 40 min to downtown Paris.

RESPONSIBILITIES

A post-doc position in bioinformatics is available to:

Unravel the regulatory logics of cell proliferation in the fish tectum. The post-doc will join in an ongoing project to search for over-represented regulatory motifs in distant elements regulating midbrain gene expressions in different vertebrate species. A set of active fish optic tectum enhancers identified in the lab will be used to predict novel midbrain enhancers.
Search for over-represented motifs around tectum stem cell specific genes. We obtained a list of genes preferentially transcribed in slow-cycling cells, which will be used as a resource to cope with the understudied question of gene regulation in stem cells. In silico predicted elements will be tested in vivo in collaboration with the AMAGEN transgenesis platform founded by the lab.

REQUIREMENTS

The successful candidate should have bioinformatics expertise in comparative genomics (regulatory elements analysis).

PREFERENCES

Additional knowledge in applied mathematics, in analysis of deep sequencing data, in developmental neurobiology, or in the use of aquatic models would be a bonus.

COMPENSATION

The two-years grant is founded in the frame of the FINEST ANR Blanc project.
Salary around 2000Euros.

HOW TO APPLY

Candidates should send a curriculum vitae, a brief summary of research experience and motivation, and contact informations for 2-3 referees. Enquiries should also be directed to this address:
Dr. Jean-Stéphane Joly, joly[at]inaf.cnrs-gif.fr

DEADLINE

7 December 2012

Discussion forums: Opportunity: Post-doc position @ CNRS Gif-sur-Yvette -- Paris, France

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