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    Science Daily: Supercomputers Help University Scientists Explore Genetics and Bioinformatics
    Submitted by J.W. Bizzaro; posted on Friday, September 08, 2000 (3 comments)

    Submitter

    ``The mapping of the human genome is the tip of the iceberg that is the biological information revolution. University of Idaho computer scientists and mathematicians are joining biologists to explore new ways to interpret the complex genetic information that describes all living things and their relationships. Along the way, UI students returning to school this fall will find a new course few schools could hope to offer: building a new supercomputer. A $500,000 National Science Foundation grant will allow James A. Foster, an associate professor of computer science, and a team of fellow scientists to build the university's expertise in bioinformatics. The network-based supercomputer known as a Beowulf cluster computer will be built with the help of the UI class taught by Robert Heckendorn, an assistant professor of computer science. It will deliver high performance computing to scientists on the Moscow campus.''

    Full story:
    www.sciencedaily.com/rele[...]0.htm

    Reference by Snowdeal.org.

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    Message
    supercomputers
    Submitted by Nobody; posted on Saturday, May 25, 2002
    Date: 25-05-2002 Ref: CDC /105/04 Dear Sir, CDC Linux Is the first Indian Linux company to commercialize supercomputing technology in the country successfully. CDC has already installed Supercomputers at premium Government Research Institutions in India and CDC Supercomputers are being currently being used at Celera Genomics and Incyte Genomics USA. CDC team consists of world-class highly skilled and motivated engineering team with expertise in Kernel (GNU/Linux , GNU Mach, GNU Hurd , OSKIT ), Networking, Security, Embedded Systems and Parallel Programming. They are imparted exhaustive training in our software development center before integrating into the regular team. Apart from that , CDC team includes a pool of PhD?s who provide their valuable domain knowledge in Bio-informatics, Weather Modeling , etc. It is backed by a highly motivated and skilled Marketing and Human Resource Development team, who are committed to CDC?s cause. CDC 1000 commercial Linux Supercomputers. These are scalable clusters of Linux nodes running parallel computer code (PVM, MPI). Multiple CDC 1000 can be connected to further scale the cluster. The whole system is packaged in rack-mounted, ready-to-use mobile enclosures and works ? out of the box?. Benchmarks have demonstrated that CDC 1000 Linux super computers achieve performances comparable to supercomputers costing millions of dollars. The rapid advances in technology (faster chips, e.g., gigabit Ethernet ) assure constant increases in performance. In supercomputing, ?uptime? is far more important than costs. The stability of Linux is key to our technology. CDC Linux based in Bangalore, India uses locally and Internationally available hardware which minimizes the cost, hassles and time delays associated with proprietary hardware (e.g., Cray, SGI.) Cost saving or monumental because our solutions cost a fraction of proprietary hardware and, since our solutions are based on Linux there are no license fees per CPU etc., Time saving 1-3 months. CDC is now Industrial Partners with CSIR under the New Millennium Indian Technology Leadership Initiative (NMITILI) on development of customized Supercomputer based parallel processing for Bio-Informatics. We would like to take this opportunity to offer you total solutions and being your partner in setting up supercomputing environment infrastructure for Research & Bioinformatics labs across the country. Similarly there are other avenues, which we would like to discuss with you in detail at a mutually convenient date and time. Thanking you & assuring you of our best co-operation at all times. Raja Seevan Head-Marketing Division CDC Linux Pvt.Ltd. "Chandrakantha Complex" # 4/5, I Cross Road Madiwala Main Road Bangalore-560 068. Phones: 91-80-550 2999 / 550 4106 / 550 4107 Fax: 080-553 6612 E-Mail: raja.seevan@californiadigital.com URL: www.californiadigital.com Mobile:98440-88174 BENEFITS OF LINUX BASED PARALLEL SUPERCOMPUTER IN THE BIO-INFORMATICS SECTOR It is in this scenario that new breeds of Supercomputers have been developed in India using the open end Linux operating system. No doubt that such systems have already been developed in other parts of the globe, but the question is ?ARE THESE AVAILABLE FOR THE INDIAN PEOPLE TO USE IT?S POTENTIAL FOR THEIR DEVELOPMENT?? The answer is a well-known fact. But with the latest development, the IT industry in India is heading for a revolutionary change. As on date MNC?s like IBM, Sun Microsystems, HP, Compaq, DELL, etc. have entered the Indian market with high-end servers based on multiple processors, which are highly priced. But not based on parallel processing. This is the major difference between the systems available in the Indian market presently and the newly Linux based Super Computer. As per the market figures of 1999, only 500 Super Computers have been sold worldwide. Of these 500, the CRAY systems occupy only 10% of the market share. This is because of their extremely high costs, trade restrictions / sanctions etc. Apart from this, specific software has to be written for the same for each and every application. Today, ?supercomputer? is a broad term describing the fastest computers available, typically used for processing large numbers or for very complicated calculations. Scientific research, weather analysis, energy research, space programs, high-end animation graphics?all require high-speed number-crunching. Latest applications involve analysis of data relating to nuclear devices, astrophysics, and space simulations etc. Parallel processing Technology hadn?t managed to produce processors that could give very high speeds consistently. The problem was tackled by using parallel processing, which involves linking hundreds, even thousands of smaller processors together. This is slightly different from distributed computing. In distributed computing, a number of smaller tasks are run concurrently on different processors linked together. In parallel processing, there?s one large task whose sub-processes are shared among the processors. This makes the software routines much more complicated and requires far more dependable hardware. The application should also be able to use a parallel algorithm, so that optimum use is made of the multiple processors operating independently and simultaneously. The development of certain? devices and advances in technology have made it easier for such machines to work seamlessly. Subsystems such as motherboards, drives, and interfaces are commercially available and highly portable across systems, while prices keep plunging. Openly available software such as Linux is increasingly being used to build Beowulf-based supercomputers. CDC Linux based Super Computer Benefits: a) Can act as a backbone server for large networks b) Can help in number crunching c) Can help in faster rendering of images d) Can help in development & implementation of educational portals e) Can be used as an ISP (Internet Service Provider) f) Can be used for conducting of exams, analysis of results, etc. g) Can be used for online admissions & registrations h) Useful tool for implementation of distant education i) Can be used for developing the digital library j) Can be used for data warehousing k) Can be used for as High-end communication servers for the telecom market. Developing countries? like India should first invest in their basic infrastructure like education, roads, and telecom. The Indian government's failure to invest in telecom infrastructure was a major drawback. Infotech for the masses is India's challenge. CDC Linux? has made extraordinary progress to date and have an ambitious growth programme, in tune to which they are committed to investing in technology, research & development and most importantly, people. Committed to their growth plan. In a market where western? Obsolete products were sold at exorbitant prices, CDC Linux is renowned to be the first to introduce the latest and most technologically advanced Supercomputers Hardware/Software solutions at competitive prices. CDC Linux has developed Linux Based parallel Supercomputers especially for Bio-informatics industry who can benefit from this cutting-edge Technology: 1. Individualized solutions for customers with specific needs in highly specialized areas requiring number crunching: a. Bioinformatics: Drug development etc., b. Computational Fluid Dynamics (CFT) wind Tunnel experiments. c. Finite Element Modeling (FEM) Weather, defence. d. Electronic Design Automation (EDA) making chips. 2. We can also offer Hardware, Software, Applications to other companies to develop their own solutions. Along with our solutions we provide maintenance training and remote systems administration. What is Bio informatics? 3. Bio-informatics the application of computer technology to the management of biological information. Supercomputers are used to gather, store, analyze and integrate biological and genetic information. The importances of Bio-informatics 4. Bioinformatics capabilities has been precipitated by the explosion of publicly available gemomic information resulting from the Human Genome project.The Goal of this project ?determination of the sequence of the entire human genome (approximately three million base pairs)-will be reached by the year 2002. The Science of Bioinformatics? 5. Which is the melding of molecular biology with computer computerscience, is essential to the use of genomic information in the understanding human diseases and in the identification of new molecular targets for drug disovery. This amount of data is shifting research? 6. In molecular biology nad genetics from a purely experimental approach to one in which experiments can be planned in front of a Supercomputer. The pace of biological research speeds up ,creating new economic opportunties for the companies, and new professional profiles in industry and academia.This is clear sign of the growing economic importance of biocomputing with supercomputers. Useful In the field of Medicine ? 7. Biocomputing techniques with supercomputers offer opportunities to Biotech companies which want to give a stronger rational basis to the process of the drug discovery. Experiments can be designed much more intelligently nad the understanding of molecular interactions can be enhanced dramatically.Trial ?nad-error experiments can be replaced by predictions that allow for the design of custom ?made-drugs.The development of safer,smarter and greener drugs is the result. Agriculture can exploit too? 8. The same computational tools ,for databases and strategies for investigating disease resistance markers, pest resistance genes and so on.As a result ,crop harvests can increase and special plants can be engineered to alleviate food shortages in India. Without supercomputers involved in biocomputing, notably sequence storage and retrieval,the various sequencing projects of the genome of man, fruit fly,bakers?s yeast and others would not be feasible. Biocomputing explosion? 9. Another area where supercomputers are a must is in the area of ?biocomputing explosion? is the introduction of new methods and algorithms, advancing computer science and technology in general. For example ,biocomputing research challenges many of the current pattern recognition techniques. The biologists need to retrieve large amounts of data from different datasets and to collerate them is pushing a head current database technologies. Supercomputer saves research time? 10. Biocomputing with supercomputers enhances drug designing ,drug specificity and side effects, the molecular basis of drug specificity, Rational drug design: The physiological effect of the drug should be clearly defined as possible. It has to specially bind to the target protein in order to minimize undesired side effects. The Supercomputer Advantage? 11. In all cases, the aim of using supercomputers for drug design is to analyze the interactions between the drug nad its receptor site and to design molecules that give an optimal fit. The techniques provide by computational methods include computer graphics for visualization and the methodology of theoretical chemistry. By using these supercomputer means of quantum mechanics the structure of small molecules can be predicted to experimental accuracy. Statistical mechanics permits molecular motion and solvent effects can be incorporated. Basically statistical mechanics is a three-dimensional of describing the position of billiard balls using Newton?s law of motion. Can out perform other supercomputers 12. These CDC Linux Supercomputers can out perform other supercomputers at fraction of the cost. Really performance to price is the bottom line, these systems will also go a long way towards solving one of the biggest drug discovery problems big pharma faces these days: data glut. Linux clusters are designed to create more server space for larger applications that require intense threading or major chunks of memory and to reduce the company?s administrative overhead in transferring data and calculations between computing platforms making users efficient. Conclusion As it involves a lot of data base searching, the more high-quality information available, the more powerful Bioinformatics can become. Bioinformatics won?t replace experiments, but can greatly streamline and enable the drug discovery. The Bottom-line. We provide total end to end solutions in High End Supercomputing Solutions, Linux deployment for Enterprise, IT Hardware, Software, Networking Solutions, Bio-Informatics Solutions, ISP?s, Data ware housing, Scientific and Engineering applications. We provide our clients high performance. We charge less than the price of any multinational companies. We complete installation/training in 1 week. We deliver in 5 Weeks. . REF: CDCL/BLORE/INTRO/2002 DATE: 1-Apr-02 Dear Sir, We are happy to give you a brief introduction about our Company. CDC Linux Private Ltd. was founded in Bangalore in May 2000. CDC Linux Pvt. Ltd., is a wholly Indian Company, registered with the Registrar of Companies, Bangalore; with Indian Directors and Indian Employees. The team comprises of a world class highly skilled and motivated engineering team with expertise in Kernel (Linux / GNU-Mach / GNU-Hurd / OS Kit), Networking, Security, Embedded Systems, Software Parallelizing and Bio-Informatics. CDC Linux is aiming to become a leading provider of Parallel Supercomputing and Clustered solutions based on the Beowulf Architecture, running the GNU/Linux Operating System. We specialize in developing highly customized GNU/Linux based scientific high performance Clusters (also known as Beowulf clusters) for Bioinformatics, CFD, Weather Modeling, CAE, Image Rendering and various other high Computational tasks. We also parallelize and port various applications onto our clusters and thus give Total Solutions to our clients. We at CDC, at the moment, are working with several Research, Defence and Govt. Agencies along with a few Pvt firms. Companies like CBT, IISC, ADA, ADE, NAL, NCBS, Biocon, Strand Genomics, GE, Astra Zeneca for providing them with affordable supercomputing solutions. CDC Group has recently acquired the server division of VA Linux Systems and we have re-launched the business of providing Linux Ultradense Servers and Clusters to enterprise clients in US. Please visit our website at www.californiadigital.com for more details. We have enclosed a detailed Company Profile for your kind reference. Thank you, Sincerely, For CDC Linux Pvt. Ltd.



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    supercomputers
    Submitted by Nobody; posted on Saturday, May 25, 2002
    Date: 25-05-2002 Ref: CDC /105/04 Dear Sir, CDC Linux Is the first Indian Linux company to commercialize supercomputing technology in the country successfully. CDC has already installed Supercomputers at premium Government Research Institutions in India and CDC Supercomputers are being currently being used at Celera Genomics and Incyte Genomics USA. CDC team consists of world-class highly skilled and motivated engineering team with expertise in Kernel (GNU/Linux , GNU Mach, GNU Hurd , OSKIT ), Networking, Security, Embedded Systems and Parallel Programming. They are imparted exhaustive training in our software development center before integrating into the regular team. Apart from that , CDC team includes a pool of PhD?s who provide their valuable domain knowledge in Bio-informatics, Weather Modeling , etc. It is backed by a highly motivated and skilled Marketing and Human Resource Development team, who are committed to CDC?s cause. CDC 1000 commercial Linux Supercomputers. These are scalable clusters of Linux nodes running parallel computer code (PVM, MPI). Multiple CDC 1000 can be connected to further scale the cluster. The whole system is packaged in rack-mounted, ready-to-use mobile enclosures and works ? out of the box?. Benchmarks have demonstrated that CDC 1000 Linux super computers achieve performances comparable to supercomputers costing millions of dollars. The rapid advances in technology (faster chips, e.g., gigabit Ethernet ) assure constant increases in performance. In supercomputing, ?uptime? is far more important than costs. The stability of Linux is key to our technology. CDC Linux based in Bangalore, India uses locally and Internationally available hardware which minimizes the cost, hassles and time delays associated with proprietary hardware (e.g., Cray, SGI.) Cost saving or monumental because our solutions cost a fraction of proprietary hardware and, since our solutions are based on Linux there are no license fees per CPU etc., Time saving 1-3 months. CDC is now Industrial Partners with CSIR under the New Millennium Indian Technology Leadership Initiative (NMITILI) on development of customized Supercomputer based parallel processing for Bio-Informatics. We would like to take this opportunity to offer you total solutions and being your partner in setting up supercomputing environment infrastructure for Research & Bioinformatics labs across the country. Similarly there are other avenues, which we would like to discuss with you in detail at a mutually convenient date and time. Thanking you & assuring you of our best co-operation at all times. Raja Seevan Head-Marketing Division BENEFITS OF LINUX BASED PARALLEL SUPERCOMPUTER IN THE BIO-INFORMATICS SECTOR It is in this scenario that new breeds of Supercomputers have been developed in India using the open end Linux operating system. No doubt that such systems have already been developed in other parts of the globe, but the question is ?ARE THESE AVAILABLE FOR THE INDIAN PEOPLE TO USE IT?S POTENTIAL FOR THEIR DEVELOPMENT?? The answer is a well-known fact. But with the latest development, the IT industry in India is heading for a revolutionary change. As on date MNC?s like IBM, Sun Microsystems, HP, Compaq, DELL, etc. have entered the Indian market with high-end servers based on multiple processors, which are highly priced. But not based on parallel processing. This is the major difference between the systems available in the Indian market presently and the newly Linux based Super Computer. As per the market figures of 1999, only 500 Super Computers have been sold worldwide. Of these 500, the CRAY systems occupy only 10% of the market share. This is because of their extremely high costs, trade restrictions / sanctions etc. Apart from this, specific software has to be written for the same for each and every application. Today, ?supercomputer? is a broad term describing the fastest computers available, typically used for processing large numbers or for very complicated calculations. Scientific research, weather analysis, energy research, space programs, high-end animation graphics?all require high-speed number-crunching. Latest applications involve analysis of data relating to nuclear devices, astrophysics, and space simulations etc. Parallel processing Technology hadn?t managed to produce processors that could give very high speeds consistently. The problem was tackled by using parallel processing, which involves linking hundreds, even thousands of smaller processors together. This is slightly different from distributed computing. In distributed computing, a number of smaller tasks are run concurrently on different processors linked together. In parallel processing, there?s one large task whose sub-processes are shared among the processors. This makes the software routines much more complicated and requires far more dependable hardware. The application should also be able to use a parallel algorithm, so that optimum use is made of the multiple processors operating independently and simultaneously. The development of certain? devices and advances in technology have made it easier for such machines to work seamlessly. Subsystems such as motherboards, drives, and interfaces are commercially available and highly portable across systems, while prices keep plunging. Openly available software such as Linux is increasingly being used to build Beowulf-based supercomputers. CDC Linux based Super Computer Benefits: a) Can act as a backbone server for large networks b) Can help in number crunching c) Can help in faster rendering of images d) Can help in development & implementation of educational portals e) Can be used as an ISP (Internet Service Provider) f) Can be used for conducting of exams, analysis of results, etc. g) Can be used for online admissions & registrations h) Useful tool for implementation of distant education i) Can be used for developing the digital library j) Can be used for data warehousing k) Can be used for as High-end communication servers for the telecom market. Developing countries? like India should first invest in their basic infrastructure like education, roads, and telecom. The Indian government's failure to invest in telecom infrastructure was a major drawback. Infotech for the masses is India's challenge. CDC Linux? has made extraordinary progress to date and have an ambitious growth programme, in tune to which they are committed to investing in technology, research & development and most importantly, people. Committed to their growth plan. In a market where western? Obsolete products were sold at exorbitant prices, CDC Linux is renowned to be the first to introduce the latest and most technologically advanced Supercomputers Hardware/Software solutions at competitive prices. CDC Linux has developed Linux Based parallel Supercomputers especially for Bio-informatics industry who can benefit from this cutting-edge Technology: 1. Individualized solutions for customers with specific needs in highly specialized areas requiring number crunching: a. Bioinformatics: Drug development etc., b. Computational Fluid Dynamics (CFT) wind Tunnel experiments. c. Finite Element Modeling (FEM) Weather, defence. d. Electronic Design Automation (EDA) making chips. 2. We can also offer Hardware, Software, Applications to other companies to develop their own solutions. Along with our solutions we provide maintenance training and remote systems administration. What is Bio informatics? 3. Bio-informatics the application of computer technology to the management of biological information. Supercomputers are used to gather, store, analyze and integrate biological and genetic information. The importances of Bio-informatics 4. Bioinformatics capabilities has been precipitated by the explosion of publicly available gemomic information resulting from the Human Genome project.The Goal of this project ?determination of the sequence of the entire human genome (approximately three million base pairs)-will be reached by the year 2002. The Science of Bioinformatics? 5. Which is the melding of molecular biology with computer computerscience, is essential to the use of genomic information in the understanding human diseases and in the identification of new molecular targets for drug disovery. This amount of data is shifting research? 6. In molecular biology nad genetics from a purely experimental approach to one in which experiments can be planned in front of a Supercomputer. The pace of biological research speeds up ,creating new economic opportunties for the companies, and new professional profiles in industry and academia.This is clear sign of the growing economic importance of biocomputing with supercomputers. Useful In the field of Medicine ? 7. Biocomputing techniques with supercomputers offer opportunities to Biotech companies which want to give a stronger rational basis to the process of the drug discovery. Experiments can be designed much more intelligently nad the understanding of molecular interactions can be enhanced dramatically.Trial ?nad-error experiments can be replaced by predictions that allow for the design of custom ?made-drugs.The development of safer,smarter and greener drugs is the result. Agriculture can exploit too? 8. The same computational tools ,for databases and strategies for investigating disease resistance markers, pest resistance genes and so on.As a result ,crop harvests can increase and special plants can be engineered to alleviate food shortages in India. Without supercomputers involved in biocomputing, notably sequence storage and retrieval,the various sequencing projects of the genome of man, fruit fly,bakers?s yeast and others would not be feasible. Biocomputing explosion? 9. Another area where supercomputers are a must is in the area of ?biocomputing explosion? is the introduction of new methods and algorithms, advancing computer science and technology in general. For example ,biocomputing research challenges many of the current pattern recognition techniques. The biologists need to retrieve large amounts of data from different datasets and to collerate them is pushing a head current database technologies. Supercomputer saves research time? 10. Biocomputing with supercomputers enhances drug designing ,drug specificity and side effects, the molecular basis of drug specificity, Rational drug design: The physiological effect of the drug should be clearly defined as possible. It has to specially bind to the target protein in order to minimize undesired side effects. The Supercomputer Advantage? 11. In all cases, the aim of using supercomputers for drug design is to analyze the interactions between the drug nad its receptor site and to design molecules that give an optimal fit. The techniques provide by computational methods include computer graphics for visualization and the methodology of theoretical chemistry. By using these supercomputer means of quantum mechanics the structure of small molecules can be predicted to experimental accuracy. Statistical mechanics permits molecular motion and solvent effects can be incorporated. Basically statistical mechanics is a three-dimensional of describing the position of billiard balls using Newton?s law of motion. Can out perform other supercomputers 12. These CDC Linux Supercomputers can out perform other supercomputers at fraction of the cost. Really performance to price is the bottom line, these systems will also go a long way towards solving one of the biggest drug discovery problems big pharma faces these days: data glut. Linux clusters are designed to create more server space for larger applications that require intense threading or major chunks of memory and to reduce the company?s administrative overhead in transferring data and calculations between computing platforms making users efficient. Conclusion As it involves a lot of data base searching, the more high-quality information available, the more powerful Bioinformatics can become. Bioinformatics won?t replace experiments, but can greatly streamline and enable the drug discovery. The Bottom-line. We provide total end to end solutions in High End Supercomputing Solutions, Linux deployment for Enterprise, IT Hardware, Software, Networking Solutions, Bio-Informatics Solutions, ISP?s, Data ware housing, Scientific and Engineering applications. We provide our clients high performance. We charge less than the price of any multinational companies. We complete installation/training in 1 week. We deliver in 5 Weeks. . REF: CDCL/BLORE/INTRO/2002 DATE: 1-Apr-02 Dear Sir, We are happy to give you a brief introduction about our Company. CDC Linux Private Ltd. was founded in Bangalore in May 2000. CDC Linux Pvt. Ltd., is a wholly Indian Company, registered with the Registrar of Companies, Bangalore; with Indian Directors and Indian Employees. The team comprises of a world class highly skilled and motivated engineering team with expertise in Kernel (Linux / GNU-Mach / GNU-Hurd / OS Kit), Networking, Security, Embedded Systems, Software Parallelizing and Bio-Informatics. CDC Linux is aiming to become a leading provider of Parallel Supercomputing and Clustered solutions based on the Beowulf Architecture, running the GNU/Linux Operating System. We specialize in developing highly customized GNU/Linux based scientific high performance Clusters (also known as Beowulf clusters) for Bioinformatics, CFD, Weather Modeling, CAE, Image Rendering and various other high Computational tasks. We also parallelize and port various applications onto our clusters and thus give Total Solutions to our clients. We at CDC, at the moment, are working with several Research, Defence and Govt. Agencies along with a few Pvt firms. Companies like CBT, IISC, ADA, ADE, NAL, NCBS, Biocon, Strand Genomics, GE, Astra Zeneca for providing them with affordable supercomputing solutions. CDC Group has recently acquired the server division of VA Linux Systems and we have re-launched the business of providing Linux Ultradense Servers and Clusters to enterprise clients in US. Please visit our website at www.californiadigital.com for more details. We have enclosed a detailed Company Profile for your kind reference. Thank you, Sincerely, For CDC Linux Pvt. Ltd.
    supercomputers
    Submitted by Nobody; posted on Saturday, May 25, 2002
    Date: 25-05-2002 Ref: CDC /105/04 Dear Sir, CDC Linux Is the first Indian Linux company to commercialize supercomputing technology in the country successfully. CDC has already installed Supercomputers at premium Government Research Institutions in India and CDC Supercomputers are being currently being used at Celera Genomics and Incyte Genomics USA. CDC team consists of world-class highly skilled and motivated engineering team with expertise in Kernel (GNU/Linux , GNU Mach, GNU Hurd , OSKIT ), Networking, Security, Embedded Systems and Parallel Programming. They are imparted exhaustive training in our software development center before integrating into the regular team. Apart from that , CDC team includes a pool of PhD?s who provide their valuable domain knowledge in Bio-informatics, Weather Modeling , etc. It is backed by a highly motivated and skilled Marketing and Human Resource Development team, who are committed to CDC?s cause. CDC 1000 commercial Linux Supercomputers. These are scalable clusters of Linux nodes running parallel computer code (PVM, MPI). Multiple CDC 1000 can be connected to further scale the cluster. The whole system is packaged in rack-mounted, ready-to-use mobile enclosures and works ? out of the box?. Benchmarks have demonstrated that CDC 1000 Linux super computers achieve performances comparable to supercomputers costing millions of dollars. The rapid advances in technology (faster chips, e.g., gigabit Ethernet ) assure constant increases in performance. In supercomputing, ?uptime? is far more important than costs. The stability of Linux is key to our technology. CDC Linux based in Bangalore, India uses locally and Internationally available hardware which minimizes the cost, hassles and time delays associated with proprietary hardware (e.g., Cray, SGI.) Cost saving or monumental because our solutions cost a fraction of proprietary hardware and, since our solutions are based on Linux there are no license fees per CPU etc., Time saving 1-3 months. CDC is now Industrial Partners with CSIR under the New Millennium Indian Technology Leadership Initiative (NMITILI) on development of customized Supercomputer based parallel processing for Bio-Informatics. We would like to take this opportunity to offer you total solutions and being your partner in setting up supercomputing environment infrastructure for Research & Bioinformatics labs across the country. Similarly there are other avenues, which we would like to discuss with you in detail at a mutually convenient date and time. Thanking you & assuring you of our best co-operation at all times. Raja Seevan Head-Marketing Division CDC Linux Pvt.Ltd. "Chandrakantha Complex" # 4/5, I Cross Road Madiwala Main Road Bangalore-560 068. Phones: 91-80-550 2999 / 550 4106 / 550 4107 Fax: 080-553 6612 E-Mail: raja.seevan@californiadigital.com URL: www.californiadigital.com Mobile:98440-88174 BENEFITS OF LINUX BASED PARALLEL SUPERCOMPUTER IN THE BIO-INFORMATICS SECTOR It is in this scenario that new breeds of Supercomputers have been developed in India using the open end Linux operating system. No doubt that such systems have already been developed in other parts of the globe, but the question is ?ARE THESE AVAILABLE FOR THE INDIAN PEOPLE TO USE IT?S POTENTIAL FOR THEIR DEVELOPMENT?? The answer is a well-known fact. But with the latest development, the IT industry in India is heading for a revolutionary change. As on date MNC?s like IBM, Sun Microsystems, HP, Compaq, DELL, etc. have entered the Indian market with high-end servers based on multiple processors, which are highly priced. But not based on parallel processing. This is the major difference between the systems available in the Indian market presently and the newly Linux based Super Computer. As per the market figures of 1999, only 500 Super Computers have been sold worldwide. Of these 500, the CRAY systems occupy only 10% of the market share. This is because of their extremely high costs, trade restrictions / sanctions etc. Apart from this, specific software has to be written for the same for each and every application. Today, ?supercomputer? is a broad term describing the fastest computers available, typically used for processing large numbers or for very complicated calculations. Scientific research, weather analysis, energy research, space programs, high-end animation graphics?all require high-speed number-crunching. Latest applications involve analysis of data relating to nuclear devices, astrophysics, and space simulations etc. Parallel processing Technology hadn?t managed to produce processors that could give very high speeds consistently. The problem was tackled by using parallel processing, which involves linking hundreds, even thousands of smaller processors together. This is slightly different from distributed computing. In distributed computing, a number of smaller tasks are run concurrently on different processors linked together. In parallel processing, there?s one large task whose sub-processes are shared among the processors. This makes the software routines much more complicated and requires far more dependable hardware. The application should also be able to use a parallel algorithm, so that optimum use is made of the multiple processors operating independently and simultaneously. The development of certain? devices and advances in technology have made it easier for such machines to work seamlessly. Subsystems such as motherboards, drives, and interfaces are commercially available and highly portable across systems, while prices keep plunging. Openly available software such as Linux is increasingly being used to build Beowulf-based supercomputers. CDC Linux based Super Computer Benefits: a) Can act as a backbone server for large networks b) Can help in number crunching c) Can help in faster rendering of images d) Can help in development & implementation of educational portals e) Can be used as an ISP (Internet Service Provider) f) Can be used for conducting of exams, analysis of results, etc. g) Can be used for online admissions & registrations h) Useful tool for implementation of distant education i) Can be used for developing the digital library j) Can be used for data warehousing k) Can be used for as High-end communication servers for the telecom market. Developing countries? like India should first invest in their basic infrastructure like education, roads, and telecom. The Indian government's failure to invest in telecom infrastructure was a major drawback. Infotech for the masses is India's challenge. CDC Linux? has made extraordinary progress to date and have an ambitious growth programme, in tune to which they are committed to investing in technology, research & development and most importantly, people. Committed to their growth plan. In a market where western? Obsolete products were sold at exorbitant prices, CDC Linux is renowned to be the first to introduce the latest and most technologically advanced Supercomputers Hardware/Software solutions at competitive prices. CDC Linux has developed Linux Based parallel Supercomputers especially for Bio-informatics industry who can benefit from this cutting-edge Technology: 1. Individualized solutions for customers with specific needs in highly specialized areas requiring number crunching: a. Bioinformatics: Drug development etc., b. Computational Fluid Dynamics (CFT) wind Tunnel experiments. c. Finite Element Modeling (FEM) Weather, defence. d. Electronic Design Automation (EDA) making chips. 2. We can also offer Hardware, Software, Applications to other companies to develop their own solutions. Along with our solutions we provide maintenance training and remote systems administration. What is Bio informatics? 3. Bio-informatics the application of computer technology to the management of biological information. Supercomputers are used to gather, store, analyze and integrate biological and genetic information. The importances of Bio-informatics 4. Bioinformatics capabilities has been precipitated by the explosion of publicly available gemomic information resulting from the Human Genome project.The Goal of this project ?determination of the sequence of the entire human genome (approximately three million base pairs)-will be reached by the year 2002. The Science of Bioinformatics? 5. Which is the melding of molecular biology with computer computerscience, is essential to the use of genomic information in the understanding human diseases and in the identification of new molecular targets for drug disovery. This amount of data is shifting research? 6. In molecular biology nad genetics from a purely experimental approach to one in which experiments can be planned in front of a Supercomputer. The pace of biological research speeds up ,creating new economic opportunties for the companies, and new professional profiles in industry and academia.This is clear sign of the growing economic importance of biocomputing with supercomputers. Useful In the field of Medicine ? 7. Biocomputing techniques with supercomputers offer opportunities to Biotech companies which want to give a stronger rational basis to the process of the drug discovery. Experiments can be designed much more intelligently nad the understanding of molecular interactions can be enhanced dramatically.Trial ?nad-error experiments can be replaced by predictions that allow for the design of custom ?made-drugs.The development of safer,smarter and greener drugs is the result. Agriculture can exploit too? 8. The same computational tools ,for databases and strategies for investigating disease resistance markers, pest resistance genes and so on.As a result ,crop harvests can increase and special plants can be engineered to alleviate food shortages in India. Without supercomputers involved in biocomputing, notably sequence storage and retrieval,the various sequencing projects of the genome of man, fruit fly,bakers?s yeast and others would not be feasible. Biocomputing explosion? 9. Another area where supercomputers are a must is in the area of ?biocomputing explosion? is the introduction of new methods and algorithms, advancing computer science and technology in general. For example ,biocomputing research challenges many of the current pattern recognition techniques. The biologists need to retrieve large amounts of data from different datasets and to collerate them is pushing a head current database technologies. Supercomputer saves research time? 10. Biocomputing with supercomputers enhances drug designing ,drug specificity and side effects, the molecular basis of drug specificity, Rational drug design: The physiological effect of the drug should be clearly defined as possible. It has to specially bind to the target protein in order to minimize undesired side effects. The Supercomputer Advantage? 11. In all cases, the aim of using supercomputers for drug design is to analyze the interactions between the drug nad its receptor site and to design molecules that give an optimal fit. The techniques provide by computational methods include computer graphics for visualization and the methodology of theoretical chemistry. By using these supercomputer means of quantum mechanics the structure of small molecules can be predicted to experimental accuracy. Statistical mechanics permits molecular motion and solvent effects can be incorporated. Basically statistical mechanics is a three-dimensional of describing the position of billiard balls using Newton?s law of motion. Can out perform other supercomputers 12. These CDC Linux Supercomputers can out perform other supercomputers at fraction of the cost. Really performance to price is the bottom line, these systems will also go a long way towards solving one of the biggest drug discovery problems big pharma faces these days: data glut. Linux clusters are designed to create more server space for larger applications that require intense threading or major chunks of memory and to reduce the company?s administrative overhead in transferring data and calculations between computing platforms making users efficient. Conclusion As it involves a lot of data base searching, the more high-quality information available, the more powerful Bioinformatics can become. Bioinformatics won?t replace experiments, but can greatly streamline and enable the drug discovery. The Bottom-line. We provide total end to end solutions in High End Supercomputing Solutions, Linux deployment for Enterprise, IT Hardware, Software, Networking Solutions, Bio-Informatics Solutions, ISP?s, Data ware housing, Scientific and Engineering applications. We provide our clients high performance. We charge less than the price of any multinational companies. We complete installation/training in 1 week. We deliver in 5 Weeks. . REF: CDCL/BLORE/INTRO/2002 DATE: 1-Apr-02 Dear Sir, We are happy to give you a brief introduction about our Company. CDC Linux Private Ltd. was founded in Bangalore in May 2000. CDC Linux Pvt. Ltd., is a wholly Indian Company, registered with the Registrar of Companies, Bangalore; with Indian Directors and Indian Employees. The team comprises of a world class highly skilled and motivated engineering team with expertise in Kernel (Linux / GNU-Mach / GNU-Hurd / OS Kit), Networking, Security, Embedded Systems, Software Parallelizing and Bio-Informatics. CDC Linux is aiming to become a leading provider of Parallel Supercomputing and Clustered solutions based on the Beowulf Architecture, running the GNU/Linux Operating System. We specialize in developing highly customized GNU/Linux based scientific high performance Clusters (also known as Beowulf clusters) for Bioinformatics, CFD, Weather Modeling, CAE, Image Rendering and various other high Computational tasks. We also parallelize and port various applications onto our clusters and thus give Total Solutions to our clients. We at CDC, at the moment, are working with several Research, Defence and Govt. Agencies along with a few Pvt firms. Companies like CBT, IISC, ADA, ADE, NAL, NCBS, Biocon, Strand Genomics, GE, Astra Zeneca for providing them with affordable supercomputing solutions. CDC Group has recently acquired the server division of VA Linux Systems and we have re-launched the business of providing Linux Ultradense Servers and Clusters to enterprise clients in US. Please visit our website at www.californiadigital.com for more details. We have enclosed a detailed Company Profile for your kind reference. Thank you, Sincerely, For CDC Linux Pvt. Ltd.
    supercomputers
    Submitted by Nobody; posted on Sunday, September 15, 2002
    Tel: 5253096 Date: 15-09-2002 Ref:EA/210/02 Dear Sir, We would like to take this opportunity to introduce ourselves as EMERALD an experienced IT (Hardware/Software) solution marketing company whose major thrust is promoting new technologies in India, in the IT industry, especially those that are relevant and which can bring about revolutionary changes. With a combined experience of over 45 man-years and supported by powerful R&D companies who have secured patents and won awards worldwide, we are now catering to the hardware and software requirements of our clients in India and overseas. We are currently priming for installation a first time in the world project for the Indian Bureau of Civil Aviation Security - an Integrated Passenger Profiling system which includes permanent record maintenance and constant updating. This is being done in co ordination with two other companies. We provide total end to end solutions in Linux deployment for Enterprise, IT Hardware, Software, Networking Solutions, High End Supercomputing Solutions, Bio-Informatics Solutions, Video streaming, Wireless Mobile Communication projects, Banking Solutions, Biometrics solutions, ISP?s, Data warehousing, Artificial Intelligence, Neural Networking, Scientific and Engineering applications and specializing in Strategic Alliances / Joint Ventures / Technology Transfers. We would like to take this opportunity to offer you total solutions in the above mentioned domains. Similarly there are other avenues, which we would like to discuss with you in detail at a mutually convenient date and time. We are driven by a belief that success is derived from working in close partnership with our clients to a common objective on a long-term basis. Thanking you & assuring you of our best co-operation at all times. Raja Seevan Chief Executive EMERALD Highend Supercomputing Solutions Provider 1128 14th Cross, Indiranagar 2nd Stage, Bangalore 560038 INDIA Tel: 3498995 , 98451 51031 E-mail:emerald_sc@hathway.com raja_seevan@yahoo.co.in

     

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