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BACKGROUND:
The Benaroya Research Institute at Virginia Mason (BRI) is an international leader in immune system and autoimmune disease research, translating discoveries to real-life applications. BRI is one of the few research institutes in the world dedicated to discovering causes and cures to eliminate autoimmune diseases such as type 1 diabetes, multiple sclerosis, arthritis and many others.

As a non-profit organization within the Virginia Mason Health System, BRI promotes clinical and interdisciplinary research, particularly in cancer, neuroscience and heart disease. Established in 1956, BRI is Washington State's oldest medical research institute.

Come join the Linsley Laboratory in Seattle, and learn to apply cutting edge big data approaches to the cure of autoimmune disease.

Who will I work with? Dr. Peter Linsley spent 30 years in the biotech and pharmaceutical industries before joining BRI in 2012, where he now focuses on developing cutting edge Systems Immunology solutions to biomarker, target and responder identification in autoimmune diseases. More information on the laboratory, projects and environment can be found on our website ([link]).

What is BRI and why do I want to work there? BRI is an internationally recognized medical research institute focused on finding cures for autoimmune and immune-mediated diseases. We stress excellence in advanced laboratory experimentation and carefully designed translational research programs. This offers our scientists the opportunity to directly impact the lives of people suffering from diseases including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies and asthma.

What is our program? The goal of our program is to train Individuals in Systems Immunology, and to apply the knowledge gained to designing and implementing insightful new experiments in basic and translational research programs of our PIs.

Systems Immunology uses bioinformatics and high throughput genomics techniques to elucidate the functioning of the immune system in health and disease, and to personalize therapies. This data-driven approach to science is emerging as a key enabling technology that will lead to cures for immune dysfunctions. Systems Immunology approaches typically employ teams of scientists, trained across a wide spectrum of disciplines, from mathematics and statistics, to modern experimental biology.

RESPONSIBILITIES:
Potential projects include linking cell ancestry and transcriptome phenotypes of disease associated T lymphocytes; and characterizing molecular profiles of lymphocyte subsets involved in autoimmune disease progression and response to therapy.

REQUIREMENTS:
We are seeking enthusiastic, highly motivated yet team-oriented individuals with an aptitude for learning and a desire to improve human health. The individuals we are seeking will hold doctoral degrees in modern experimental immunology, mathematics, statistics and/or bioinformatics. Experience in experimental science, genomics, sequence analysis, data modeling and visualization, and statistics is desirable, but not essential, as training opportunities will be provided.

LOCALE:
Seattle, WA

TERMS:
Status: Full time

COMPENSATION:
Depends on experience

HOW TO APPLY:
Please visit [link].

Position #: 2016-1297
Title: Bioinformatics Postdoctoral Research Associate
Department: Systems Immunology

DEADLINE:
Open until closed

POLICY:
BRI is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status, such as race, religion, color, national origin, sex, age.

BACKGROUND:
Highly motivated Software Developer/Bioinformatician to join a new international collaboration to create a cancer organoid biobank.

An exciting IT opportunity has become available at the Wellcome Trust Sanger Institute as part of an international effort to generate a large cancer organoid biobank. The aim of this project is to develop cancer organoid models that allow basic biological questions to be addressed, more rapid and accurate drug testing, and influence the treatment options on an individual patient basis.

RESPONSIBILITIES:
The successful candidate will join a large multi-disciplinary team and be tasked with developing the IT infrastructure for this important venture. The role will involve working closely with scientific and IT staff within the Cancer Programme to develop and implement novel analysis strategies and sample tracking systems to support this study. In addition, the role will involve improving existing algorithms and developing new database systems to hold clinical data.

REQUIREMENTS:
We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of cancer.

Essential Skills:
* Good degree in Bioinformatics or Computer Science with a scientific background
* Software development skills in one of Perl, Python, Java or C/C++
* ORACLE/MySQL databases
* Enjoy working as part of a team

PREFERENCES:
Ideal Skills:
* Experience of statistical analysis in bioinformatics
* Experience of handling Next Generation sequencing data
* LSF or Open Grid scheduling software
* Experience of workflow management IT systems
* Experience working, developing and compiling software tools in a UNIX/LINUX environment.
* Experience of working in an Agile Software Development Group
* Web development using Perl, Java, HTML(5), CSS, JavaScript
* Background in cancer genetics
* Excellent communication skills

ABOUT US:
The Wellcome Trust Sanger Institute operates at the forefront of genomics, sequencing and analyses targeting a wide range of genomes from single cell pathogens to higher vertebrates, with an emphasis on genomes relevant to human medicine and welfare.

The Cancer Genome Project at the Institute has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers (http://www.sanger.ac.uk/genetics/CGP/).

The IT group has developed a suite of algorithms to analyse genetic variation in cancer genome data. This includes software to detect tumour genetic variation (e.g. single-base substitutions, structural rearrangements, copy number changes) and the ability to annotate the resulting variants and mine the data for interesting patterns and signatures.

COMPENSATION:
Salary range: GBP 31033 to GBP 39142per annum plus excellent benefits.

Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

HOW TO APPLY:
Application link: [link]

Please include a covering letter and CV with your application.

Please state your current salary in the covering letter.

DEADLINE:
Closing date: 9th March 2016

BACKGROUND:
We are looking for an experienced computational biologist to perform research analyses and manage the informatics infrastructure for two major ongoing translational genetics studies focusing on rare developmental disorders, within the research group of Matthew Hurles, working closely with our clinical collaborators.

The Deciphering Developmental Disorders (DDD) study (http://www.ddduk.org) is the world's largest genome-wide sequencing study of children with severe developmental disorders, with almost 14,000 families recruited from across the UK and Ireland. The DDD study is resulting in the diagnosis of thousands of previously undiagnosed children and is having major translation (PMID: 25529582) and research (PMID: 25533962) impact.

The Prenatal Assessment of Genomes and Exomes (PAGE) study (http://www.pageuk.org) is focusing on the use of genome-wide sequencing to provide accurate prognostic information for ~1,000 UK fetuses with structural anomalies identified by prenatal ultrasound.

RESPONSIBILITIES:
The vast amount of data generated by the DDD and PAGE studies require careful data management, robust processing pipelines and sophisticated research analyses. The successful applicant for this role will work with a Senior Computational Biologist to maintain and develop the existing informatic infrastructure for the two projects. The successful applicant will also lead on specific research projects befitting their interests and expertise, leveraging these incredibly rich and powerful datasets, as an integral part of the analytical team of post-docs and students working on these studies.

REQUIREMENTS:
Essential Skills:
As detailed in the Role Profile, of particular note are strong skills and experience in UNIX/LINUX and scripting languages (e.g. Perl,Python) and expertise in genetics and/or bioinformatics.

PREFERENCES:
Ideal Skills:
As detailed in the Role Profile, of particular note are experience in NGS/exome analysis, familiarity with high throughput computing environments, and a track record of publications in genetics.

COMPENSATION:
Salary GBP 38413 to GBP 48869 per annum depending on experience (Principal Computer Biologist)
Salary GBP 31033 to GBP 39142 per annum depending on experience (Senior Computer Biologist)

Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

ABOUT US:
The Sanger Institute is a charitably funded research centre that applies the power of genomics to uncover the basis of genetic and infectious disease. We conduct science at a scale and speed that sets our research apart. Our passion is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

HOW TO APPLY:
Please visit: [link]

Please include a covering letter and CV with your application.

DEADLINE:
Closing date: 17th February 2016

BACKGROUND:
Spotify Analytics tackles complex, data-intensive research questions, builds data platforms and apps, and cultivates Spotify's data-first culture. You will have a hand in building the world's leading analytics organization.

RESPONSIBILITIES:
As a data engineer, you will partner with data scientists, visualization designers, and other developers to mine billions of listening hours from millions of users for insights and solutions to a wide range of product, content, marketing, and business problems. You will invent and employ innovative practices and tools to ingest, move, process, store, and expose consumer-scale datasets and will play a key role in improving the quality of our data and large scale data infrastructure. You will work with high-level data processing frameworks like Scalding, Spark, or Crunch. Above all, your work will impact the way the world experiences music.

REQUIREMENTS:
Bachelors, Masters, or Ph.D.

LOCALE:
New York, London, San Francisco, Boston, and Stockholm

COMPENSATION:
Commensurate to Experience

HOW TO APPLY:
Please email krystan[at]spotify.com. ***UPDATED***

DEADLINE:
3/8/16

DESCRIPTION:
The Center for Infection and Immunity (CII) - one of the world's most advanced academic centers for research in infectious disease surveillance, diagnosis and discovery is seeking an experienced individual for a Sr. Programmer Analyst position on its Bioinformatics team. The successful applicant will join a large and dynamic laboratory consisting of approximately 65 personnel at Columbia and a global network of researchers who work on projects related to infectious disease surveillance and discovery in humans and wildlife as well as autism and chronic fatigue syndrome/myalgic encephalomyelitis.

The candidate is expected to demonstrate the following skills:
* At least two to three years of experience in bioinformatics, writing pipelines and analysis of next generation sequencing data from Illumina and other sequencing platforms. The candidate is expected to have basic knowledge of 16s rRNA data analysis using Qiime software for microbiome studies.
* The candidate should have good knowledge of NGS data quality control, mapping software such as Bowtie, BWA or STAR, de-novo assembly software and alignment programs such as BLAST and USEARCH, with a solid understanding of algorithms behind them.
* Basic knowledge of genetics and molecular biology as well as practical knowledge of major bioinformatics tools and resources (NCBI, UCSC)
* The position requires the ability to work in Unix environments consisting of high performance clusters. The candidate should have a good understanding of multi-threading tools (SGE, MPI), resource management and allocation.
* At least two to three years of academic or industrial experience working with scripting languages, such as Shell, Python, Perl and R. Desired qualifications include: applied biology/mathematics/statistics/biostatistics background.
* The candidate will perform other duties as assigned.

The individual should be highly motivated and enjoy work in a fast paced environment. Salary will be competitive and commensurate with experience. Columbia offers a comprehensive and attractive benefits package (Benefits Highlights for Officers 2015 - http://hr.columbia.edu/benefits/bib)

Duties and Responsibilities:
Provide bioinformatics support for microbiome analysis in a large and dynamic laboratory - 40%
Provide support for projects related to viral detection and discovery - 40%
Manage databases - 5%
Contribute to publications and research grants - 5%
Assist with training personnel - 5%
Perform other related duties as assigned - 5%

Minimum Qualifications:
Requires a bachelor's degree in bioinformatics, or computer science and at least four years of experience in bioinformatics.

Preferred Qualifications:
Master's degree with 2 years of related experience

HOW TO APPLY:
All applications must be submitted via Columbia's online hiring system: [link]

POLICY:
Columbia University is an Equal Opportunity/Affirmative Action employer.

RESPONSIBILITIES:
Principal duties:
The successful candidate will be responsible for evaluating, developing, and overseeing the Informatics and Information Technology (IIT) components of the Great Lakes Bioenergy Research Center (GLBRC) at the University of Wisconsin-Madison, partnering with national laboratories and several academic institutions. The GLBRC is one of three Department of Energy centers tasked to conduct fundamental, genomics-based research on microbial and plant systems to generate technology for the conversion of lignocellulosic biomass to biofuels and chemicals.

The GLBRC IIT Director will lead day-to-day activities that focus on the highest-quality customer service and provide access to modern information technology. The IIT Director will assemble, organize, and direct informatics support of research and operational missions, as well as promote communication and collaboration among faculty and staff. The IIT Director will develop and direct the strategic and tactical planning to address center-wide issues.

Under the general direction of the GLBRC Associate Director, the IIT Director is responsible for leading a team of professional staff in the development, implementation, and support of the Centers' data management and analysis infrastructure. In addition, the IIT Director is responsible for maintaining working relations with computational biology staff who are embedded in various research programs within the Center. The individual requires extensive experience, resourcefulness, and creativity to anticipate and develop the Center's unique scientific computational resources.

This position provides oversight of the IIT infrastructure in collaboration with faculty, researchers, and operations staff. The successful candidate must have the ability to lead a team using modern software development procedures, such as agile development and test-driven software development. Significant responsibilities include providing vision, leadership, scientific expertise, and problem-solving skills in the development of a reliable LIMS system and bioinformatics support. These systems and procedures must handle the variety of data types generated and data analyses needed by GLBRC researchers, as well as the database infrastructure that ensures data integrity, compliance, and the development of well-designed interfaces that meet the needs of researchers in GLBRC. Informatics systems at GLBRC have stakeholders at other academic institutions, national laboratories, and Bioenergy Research Centers (BRCs) nationally, as well as partners at JGI (Joint Genome Institute) and DOE (Department of Energy).

The IIT Director will work with Center management to develop the GLBRC's informatics strategy in consideration of the mission, goals, and objectives for the Center; to develop annual IIT budgets based on periodic needs assessment and feedback from the GLBRC Management Team; to monitor IIT expenditures to ensure compliance with available budget; and to manage and oversee long-range and short-term IIT needs and purchase necessary equipment to ensure a progressive IIT unit.

Oversight of Information Technology will require the IIT Director to have the ability to either critique existing or develop updated back-up and disaster recovery policies to ensure security of all information systems, data, and equipment; center-wide policies and documentation regarding operations, computer use, data center facilities, and security; and priorities for the development of new services and facilities.

The IIT Director will ensure a positive and supportive work environment for professional staff in the IIT unit; develop individual performance standards for employees and direct progress through regular performance feedback and evaluations; forecast future staff and equipment needs and secure resources to assure that needs are met; assess both technical and financial aspects of decisions to ensure feasibility and cost effectiveness; hire exceptional IIT staff; and orient and train new IIT staff.

The IIT Director is an active member of the GLBRC Management Team and will be expected to travel to meetings and conferences as a representative of the team.

Joining the Great Lakes Bioenergy Research Center is a unique opportunity to play a key role in a premier research center tasked with a mission of great societal importance - sustainable bioenergy. For additional information regarding the GLBRC, visit our website: http://www.glbrc.org.

REQUIREMENTS:
Degree and area of specialization:
The candidate must have either a Masters or PhD in computational biology, bioinformatics, biostatistics, or computer science with a strong background in biology or, alternatively, a PhD in Biochemistry, Genetics, or a related field with extensive experience in computational biology.

Minimum number of years and type of relevant work experience:
The candidate must have 10+ years of experience in an academic, scientific, or biotechnology environment. The ideal candidate is a highly motivated team leader with strong understanding of biology and software engineering. Broad knowledge of current bioinformatics methodologies and ability to adapt to the needs of this rapidly evolving field is expected. Proven success as a manager must include experience in organizational capability, leveraging change as an opportunity, and providing support to foster positive working relationships at all levels. A successful candidate will provide evidence of outstanding performance in previous roles, demonstrated ability in delivering technology solutions in a dynamic environment, and customer service skills that include managing expectations and relationships. Outstanding problem-solving ability; experience leading software development teams using relational databases and modern programming languages, (e.g., Ruby, Python); knowledge of laboratory information management systems (LIMS) or other large-scale data management systems; and familiarity with processing and analysis of large-scale "-omics" data using compute clusters / high-performance computing are required.

Candidates should have solid experience building effective tools for scientists, especially in the areas of data management, analysis, and visualization.

Experience in integrative analysis and interpretation of large-scale data in the context of biological pathways and networks, sound knowledge of systems-level biological data and expertise in analysis and interpretation of genomics and other "-omics" research data, proven expertise in accurately estimating and adhering to budgets and schedules, excellent written and oral presentation skills, and a demonstrated ability to develop collaborative relationships with national programs and institutions are desirable.

HOW TO APPLY:
In order to apply, applications must be submitted online at [link].

DEADLINE:
To ensure consideration, applications must be received by March 1, 2016.

POLICY:
A criminal background check will be conducted prior to hiring.

A period of evaluation will be required.

NOTE: Unless confidentiality is requested in writing, the names of applicants must be released upon request. Finalists cannot be guaranteed confidentiality. In the case where there are fewer than five finalists, the names of the five most qualified candidates must be released upon request.

UW-Madison is an equal opportunity/affirmative action employer. We promote excellence through diversity and encourage all qualified individuals to apply.

See complete job ad here: [link]

BACKGROUND:
The German Center for Neurodegenerative Diseases (DZNE) is a center of excellence within the Helmholtz Association that performs translational research on neurodegenerative diseases. The center includes nine excellence sites in Berlin, Bonn, Dresden, Göttingen, Magdeburg, Munich, Rostock/Greifswald, Tübingen and Witten.

The research group of computational systems biology headed by Stefan Bonn at the DZNE in Göttingen offers an open position for a bioinformatics researcher. DZNE Göttingen has a specific focus on genome-environment interactions and epigenetic processes in neurodegenerative diseases.

RESPONSIBILITIES:
The successful candidate will work within a team of bioinformaticians in a multidisciplinary environment spanning bioinformatics, systems biology, and neuroscience. The work will focus on the development of novel algorithms, workflows, and software for the integrative analyses of various genome-wide datasets derived from massively parallel sequencing (single cell RNA-seq, small RNA-seq, ChIP-seq, MeDIP-seq, WGB-seq, WG-seq, and exome-seq).

REQUIREMENTS:
Candidates should have a strong background in bioinformatics, computational biology, or computer science, be looking for a collaborative and dynamic environment, and have a proven track record of productivity. Prior experience with professional software development, machine learning, and text mining is an asset but not a requirement.

COMPENSATION:
We Offer:
* An interesting and challenging task in a research center that works on the future topics of health research
* A strongly cooperative and supportive international environment with state-of-the-art research facilities and equipment
* A high potential for the individual development of our employees
* Targeted personnel development
* Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst)

HOW TO APPLY:
Applicants should send a letter of research interests, curriculum vitae, the names and contact details of two referees to Stefan.Bonn[at]dzne.de. Please indicate `Staff Bioinformatician' in the title of the e-mail.

POLICY:
The DZNE is an equal opportunity employer. The DZNE is committed to employing disabled individuals and especially encourages them to apply.

BACKGROUND:
Berkeley Lab is Bringing Science Solutions to the World, and YOU can be a part of it!

In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with "excellence." That's why we hire the best - whether in research, finance or other operations. This is a great opportunity to bring your top-notch skills to bear in support of world-class scientific research that addresses national and global challenges!

Position Summary:
Within the Berkeley Lab's Environmental Genomics & Systems Biology Division, the Monarch Initiative (http://monarchinitiative.org/) is seeking a passionate and motivated individual to join its cross-functional and internationally collaborative project. We develop and apply cutting-edge approaches for analyzing cross-species genotype-phenotype data to enable biomedical and disease discovery in an open-source framework. We are looking for someone to help us build the world's largest phenotypic knowledge base, and to develop innovative ways to access and use this knowledge.

This is a fantastic opportunity to help Monarch grow it's knowledge store to new levels. If you like to poke at data and discover how animal models can translate into biomedical insight, then this is the ideal opportunity for you.

RESPONSIBILITIES:
Software Developer 3:
* Integrate new data sets of interest into our graph-based knowledge store
* Probing the data with interesting biological questions to test the correctness of the data model
* Implement new visualizations over the data
* Wrangling large datasets, including collaborating on innovative methods for storing and processing data
* Develop new solutions to intelligently automate the accumulation of phenotypic knowledge and datasets
* Implement substantial, known or novel, computational methods to improve the analysis capabilities and output of the group
* Troubleshoot systems and data problems and select appropriate solutions
* Participate in formal and informal design and code reviews
* Present progress at internal group meetings

In addition to the above responsibilities, the Software Developer 4 will:
* Identify, model, and integrate new data sets of interest
* Discover novel biological insights
* Designing and implement new visualizations over the data
* Troubleshoot diverse and challenging systems and data problems and exercise independent judgment to select appropriate solutions
* Present progress at research conferences

REQUIREMENTS:
Software Developer 3:
* Bachelor's degree or equivalent plus 4 years of related experience in computer science, genetics, bioinformatics or related field
* Experience in wrangling and using biomedical data
* Determine methods and procedures on new or existing software solutions
* Quantitative training with basic understanding of probability and statistics
* Ability to be self-driven and work well together in a cross-functional and interdisciplinary team
* Proficiency in Unix environments
* Programming experience in:
- Scripting languages such as Python
- Analysis using statistical and machine learning tools, such as R, Weka, and scikit-learn
- Experience with various databases and their query languages, such as SQL, SPARQL or Neo4j/Cypher
* Experience with communicating results and concepts to a diverse audience including geneticists, engineers, laboratory scientists
* Travel once per year
* Attention to detail

In addition to the above qualifications, the Software Developer 4 will have:
* MS or PhD with equivalent experience in computer science, genetics, bioinformatics, or related field
* Familiarity with development or management of pipelines in production environments
* Experience with semantic web, ontologies, their application, and analysis
* Experience with high performance computing environments and/or cloud-based environments
* Experience with genome and/or phenome-wide association studies or human population genetics / statistical genetics including imputation and haplotyping
* Proficient with Java or JVM languages such as Scala or Groovy
* Represent the Laboratory at conferences 2-3 times per year

TERMS:
Notes: This is a 1 year, term appointment with the possibility of renewal and with the possibility of conversion to career. Classification will depend upon the applicant's level of skills, knowledge, and abilities.

ABOUT US:
Berkeley Lab addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.

HOW TO APPLY:
Apply directly online at http://50.73.55.13/counter.php?id=58332 and follow the on-line instructions to complete the application process.

DEADLINE:
The posting shall remain open until the position is filled.

POLICY:
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4 ([link]). Click here ([link]) to view the poster and supplement: "Equal Employment Opportunity is the Law."

This position requires completion of a background check.

DESCRIPTION:
Epigenetics, Gene Regulation and 3D Genome Architecture

About the La Jolla Institute:
The La Jolla Institute for Allergy & Immunology (LIAI), an independent, non-profit research institute, is seeking talented and highly motivated postdoctoral fellows specializing in bioinformatics and computational biology to join Ferhat Ay's Lab (http://www.liai.org/pages/ay-home) in San Diego, CA.

RESPONSIBILITIES:
Successful candidates will conduct research in a dynamic and a highly collaborative environment. The research will involve development of novel computational methods for analysis and integration of large-scale, heterogeneous data sets in order to link epigenetic mechanisms, such as the three-dimensional organization of chromatin, to gene regulation. The developed methods will also be applied to first-hand data produced in collaboration with top-notch research groups at the institute, in San Diego area or elsewhere.

REQUIREMENTS:
* Ph.D. with a strong background in Computer Science, Statistics, Machine Learning or Bioinformatics
* Excellent programming skills in at least one programming language (preferably Python)
* Proven record of scientific publications in bioinformatics and/or genomics journals
* Ability to develop novel computational methods, algorithms and data processing pipelines
* Excellent communication and presentation skills
* Willingness to work closely with experimental biologists

HOW TO APPLY:
Interested individuals should send their CV and a brief (one page) research statement to: ferhatay[at]liai.org or apply directly at [link]

BACKGROUND:
The La Jolla Institute for Allergy & Immunology, an independent, non-profit research institute, is seeking a talented and highly motivated postdoctoral fellow specializing in bioinformatics to join Bjoern Peters' lab (http://www.liai.org/pages/faculty-peters) in San Diego, California.

About the La Jolla Institute:
LJI is a great place to work as a postdoc. It was recently ranked as one of the world's top 5 immunology research institutes based on literature citations, and was ranked #1 in a survey of postdocs as `best places to work' worldwide by the Scientist.

RESPONSIBILITIES:
Research Area:
The individual to be hired will build software tools to analyze experimental data and predict epitope targets of immune responses. The resulting tools will be made available in the IEDB (http://www.iedb.org), an NIH-funded bioinformatics resource with a large user base in academia and industry. Also, tools will be directly applied in multiple in-house projects to develop improved diagnostics, vaccines and immunotherapeutics in the Peters and Sette lab.

REQUIREMENTS:
* Ph.D. degree ideally in bioinformatics, candidates with equivalent skills and interests in computer science, statistics, and biomedicine will also be considered.
* Fluency in at least one programming language and the ability to quickly master new tools is required; practical experience with Python, Perl, R, Java, C/C++, Linux, and web server development (ideally Django) is desirable.
* Knowledge of immunology, biochemistry, and bioinformatics is a strong plus.
* Superior communication skills and the ability to work in an interdisciplinary team are essential.

HOW TO APPLY:
Interested candidates MUST include their CV, cover letter, and the names of three references to be considered. Please send them to bpeters[at]lji.org

BACKGROUND:
The La Jolla Institute for Allergy & Immunology, an independent, non-profit research institute, is seeking a talented and highly motivated postdoctoral fellow specializing in bioinformatics to join Bjoern Peters' lab (http://www.liai.org/pages/faculty-peters) in San Diego, California.

About the La Jolla Institute:
LJI is a great place to work as a postdoc. It was recently ranked as one of the world's top 5 immunology research institutes based on literature citations, and was ranked #1 in a survey of postdocs as `best places to work' worldwide by the Scientist.

RESPONSIBILITIES:
Research Area:
The individual hired for the immune profiling position will work at the cutting edge of bioinformatics, immunology and epigenetics, analyzing large-scale integrated datasets including genomic, epigenomic and transcriptomic profiles derived from human immune cells. The majority of this research will focus on immune signatures of protection from and susceptibility to dengue fever and tuberculosis in latently, or acutely infected or vaccinated individuals as part of a large NIH-funded collaborative project.

REQUIREMENTS:
* Ph.D. with a strong background in bioinformatics, biostatistics, and large-scale dataset analysis
* Excellent communication and programming skills
* Great publication record
* Strengths in problem-solving skills and creative thinking
* Ability to build new software tools as needed
* Dual background in both computation and molecular biology, ideally focusing on immunology, will be a strong plus, as is prior experience with sequencing analysis

HOW TO APPLY:
Interested candidates MUST include their CV, cover letter, and the names of three references to be considered. Please send them to bpeters[at]lji.org

BACKGROUND:
We are looking for candidates interested in working with us to develop the next generation of software tools for microbiome analysis, and to apply those to understand how bacterial communities and their products modulate pathogenesis and disease progression. You will develop and implement new analytical methods that make use of state-of-the-art technology. These tools will be applied to a variety of different research projects to answer both basic science and translational questions. At Mount Sinai you will have the opportunity to work closely with world-renowned scientists and clinicians of varied expertise, ranging from genomics to immunology, pediatrics or gastroenterology.

REQUIREMENTS:
* A B.Sc. or PhD in Computer Science, Engineering, Genomics or similar
* Programming skills (Python and/or R) and familiarity with Unix are essential.
* Excellent written and spoken English and the ability to present regularly to large groups within Sinai or at scientific conferences are required.
* Previous experience with software development methodologies (version control, unit testing) is highly desirable.
* Experience with high-performance clustering environments and analysis of large biological datasets are a plus.

ABOUT US:
Our lab is part of the Icahn Institute for Genomics & Multiscale Biology, the Department of Genetics & Genomic Sciences and the Immunology Institute at the Icahn School of Medicine at Mount Sinai. We are located in Manhattan, New York, right next to Central Park. If you are interested in learning more about the lab, please visit http://www.clementelab.org

HOW TO APPLY:
Please send us a cover letter, your CV (including the name of three references), and examples of code you have previously written to jobs[at]clementelab.org

BACKGROUND:
The Regeneron Genetics Center, a wholly-owned subsidiary of Regeneron Pharmaceuticals, is organized to collaborate with health systems and research groups to elucidate, on a large scale, genetic factors that cause or influence a range of human diseases. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the Center will specialize in ultra-high-throughput exome sequencing and computational biology; discovery of genotype-phenotype associations through linkage to well-annotated de-identified patient electronic medical records; and validation of discoveries using Regeneron's VelociGene® technology. Our interests encompass a breadth of different areas such as Mendelian and family frameworks, large-scale population genetics (both common and rare variants), and gene-gene interactions. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and patients of collaborating health-care systems, and identifying novel targets for drug development.

RESPONSIBILITIES:
We are looking for a Senior Software Engineer to join the Regeneron Genetics Center's Clinical Informatics team to help build and continue to scale Clinical Informatics' (CI) big data infrastructure and tools that supports the workflow and analysis of scientists throughout the RGC and Regeneron. As an SSE at the RGC, you will have the opportunity to use bleeding-edge data technologies to advance science and healthcare.

Key Responsibilities:
* Build out a big data distributed architecture capable of efficiently processing terabytes of clinical and genomic data.
* Develop and maintain web applications used by Regeneron scientists to analyze clinical datasets.
* Develop parallelized algorithms and tools to analyze large graph models consisting of millions of nodes and billions of edges.
* Build automation around various components of the system.
* Interact with scientists and staff to clearly define and iterate on requirements.
* Learn and leverage modern, best-of-breed software technologies and practices, including: Spark, Hadoop, various NoSQL databases, AWS, React, and Functional Programming.

REQUIREMENTS:
* Minimum of BS in Computer Science or related field
* 3+ years of software engineering experience in a modern Object Oriented or Functional language
* Experience with large distributed systems
* Experience with Spark, Hadoop, or related frameworks/databases
* Experience with client side software development (HTML, JavaScript, CSS, etc)
* Working knowledge of SQL
* An ability to quickly absorb domain knowledge related to Clinical Informatics
* A desire to innovate through prototyping and experimentation

PREFERENCES:
Experienced software developer with a strong background using Spark, Hadoop, or related frameworks/databases. Ability to quickly absorb domain knowledge related to Clinical Informatics.

TERMS:
N/A

LOCALE:
777 Old Saw Mill Road, Tarrytown, NY 10591

COMPENSATION:
Level will be commensurate with experience.

HOW TO APPLY:
Visit careers.regeneron.com and search by 5662BR

For job inquiry, please contact yushen.chang[at]regeneron.com .

DEADLINE:
No deadline

POLICY:
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

RESPONSIBILITIES:
The Dana-Farber Cancer Institute (DFCI) seeks outstanding candidates at the level of Assistant Professor or Associate Professor. The successful candidate will hold an academic appointment in the Department of Biomedical Informatics at Harvard Medical School (a candidate who is a practicing physician will be appointed in the Department of Medicine at Harvard Medical School) and will be based at DFCI in the Department of Biostatistics and Computational Biology. Academic rank will be determined in accordance with the successful candidate's experience and productivity.

HMS and DFCI are seeking an accomplished and innovative cancer genome computational biologist or biomedical informatician who intends to develop the intellectual and computational framework for the use of genomic analysis in cancer diagnosis. Areas of focus could include but are not limited to approaches to the analysis of next-generation sequencing data for the identification of DNA or RNA alterations, the development of computational methods for new genome analysis technologies, and the development of knowledge systems to interpret cancer genome alterations based on biological and clinical data. There will be extensive opportunities to collaborate with oncologists, pathologists and surgeons in developing and applying new diagnostic methods to achieve impact on cancer care.

REQUIREMENTS:
Candidates should have an M.D., Ph.D. or M.D./Ph.D. degree, with a significant record of discoveries and a record of publishing these discoveries in peer-reviewed journals.

LOCALE:
Boston, MA

HOW TO APPLY:
Applicants should send a letter of application, including a statement of current and future research interests, curriculum vitae, sample publications, and the names of four referees to chair[at]jimmy.harvard.edu. Applicants should ask their four referees to write independently to this address. Consideration of candidates will begin after the application package is complete.

DEADLINE:
February 29, 2016

RESPONSIBILITIES:
The Dana-Farber Cancer Institute (DFCI) seeks an accomplished and innovative research faculty member. Pursue basic and translational research with an emphasis on solving biological problems by computational and data science methods. Collaborate with cancer researchers to achieve impact on data-driven clinical trials and cancer care in the age of genomically informed personalized medicine. Join a new Center focused on computational biomedicine, headed by Chris Sander. Home will be in the Department of Biostatistics and Computational Biology at DFCI with an academic appointment in the Department of Biomedical Informatics at Harvard Medical School (HMS). Participate in the scientific events of the Dana-Farber, Harvard and Boston area research communities and train graduate students in a highly interactive, supportive, collaborative and dynamic research environment.

REQUIREMENTS:
You have a Ph.D. or M.D./Ph.D. degree, with a significant record of discoveries and peer-reviewed publications. Your academic rank will be determined according to your experience and productivity.

LOCALE:
Boston, MA

HOW TO APPLY:
Send a letter of application and a concise statement of current and future research interests, curriculum vitae, sample publications, and the names of four referees to chair[at]jimmy.harvard.edu and ask referees to independently provide letters of recommendation to the same address. Consideration of candidates will begin after the application package is complete.

DEADLINE:
February 28, 2016

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