MDT15 - L-lactate dehydrogenase - Plasmodium falciparum (isolate CDC / Honduras)

Target Protein
AccessionMDT15
NameL-lactate dehydrogenase
SynonymsLDH-P
SourcePlasmodium falciparum (isolate CDC / Honduras)
Function(S)-lactate + NAD+ = pyruvate + NADH
Cellular Location-
Target Present in HumanYes, Swiss-Prot:
Q6ZMR3
Q9BYZ2
P00338
P07195
P07864
Q86WU2
Sequence
MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCK
VSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNA
FIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVG
AHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPA
AAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKA
KFDEAIAETKRMKALA
Structure
PDBResolutionMethodInhibitor
1CEQ2X-ray Crystallography-
Other related entries: 1CET 1LDG 1T24 1T25 1T26 1T2C 1T2D 1T2E 1U4O 1U4S 1U5A 1U5C 1XIV 2A94 
Visualize active sites, motifs, domains and more >>>
Comments-
LinksSwiss-Prot: Q27743  PlasmoDB: PF13_0141
References
  • Dunn CR, Banfield MJ, Barker JJ, Higham CW, Moreton KM, Turgut-Balik D, Brady RL, Holbrook JJ. The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design Nat Struct Biol. 1996 Nov;3(11):912-5.  [PubMed - 8901865]
  • Cameron A, Read J, Tranter R, Winter VJ, Sessions RB, Brady RL, Vivas L, Easton A, Kendrick H, Croft SL, Barros D, Lavandera JL, Martin JJ, Risco F, Garcia-Ochoa S, Gamo FJ, Sanz L, Leon L, Ruiz JR, Gabarro R, Mallo A, Gomez de las Heras F. Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity. J Biol Chem. 2004 Jul 23;279(30):31429-39. Epub 2004 Apr 26.  [PubMed - 15117937]
  • Brady RL, Cameron A. Structure-based approaches to the development of novel anti-malarials. Curr Drug Targets. 2004 Feb;5(2):137-49.  [PubMed - 15011947]
  • Royer RE, Deck LM, Campos NM, Hunsaker LA, Vander Jagt DL. Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles. J Med Chem. 1986 Sep;29(9):1799-801.  [PubMed - 3528492]
  • Read JA, Wilkinson KW, Tranter R, Sessions RB, Brady RL.  Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase. J Biol Chem. 1999 Apr 9;274(15):10213-8.  [PubMed - 10187806]
  • Gomez MS, Piper RC, Hunsaker LA, Royer RE, Deck LM, Makler MT, Vander Jagt DL. Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum. Mol Biochem Parasitol. 1997 Dec 1;90(1):235-46.  [PubMed - 9497046]
  • Deck LM, Royer RE, Chamblee BB, Hernandez VM, Malone RR, Torres JE, Hunsaker LA, Piper RC, Makler MT, Vander Jagt DL.  Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum. J Med Chem. 1998 Sep 24;41(20):3879-87.  [PubMed - 9748363]
  • Bzik DJ, Fox BA, Gonyer K. Expression of Plasmodium falciparum lactate dehydrogenase in Escherichia coli. Mol Biochem Parasitol. 1993 May;59(1):155-66.  [PubMed - 8515777]