Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53. J Gen Virol 83, 2765-2772 (2002).
hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53
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Analysis of p53 "latency" and "activation" by fluorescence correlation spectroscopy. Evidence for different modes of high affinity DNA binding. J Biol Chem 278, 32587-32595 (2003).
p53 has different modes of high affinity DNA binding which are related to its tumor suppressor functions
p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11, 577-590 (2003).
p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release
Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 424, 516-523 (2003).
transcription of the p53 gene is induced by IFN-alpha/beta, accompanied by an increase in p53 protein level, contributing to tumour suppression and critical for antiviral defence
Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity. Proc Natl Acad Sci U S A 100, 9934-9939 (2003).
Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity.
Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A. J Biol Chem 277, 14102-14108 (2002).
Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A; in addition, Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A.
Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification. J Biol Chem 278, 52890-52900 (2003).
p53 post-translational modification has a role in p53 inactivation in malignant epithelial cells with mdm2 gene amplification
p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. J Biol Chem 277, 50206-50213 (2002).
ultraviolet rays increase the specificity of CK2 for p53 at the expense of other cellular CK2 substrates and leading to an overall increase in p53 serine 392 phosphorylation
mRTVP-1, a novel p53 target gene with proapoptotic activities. Mol Cell Biol 22, 3345-3357 (2002).
Identification of a novel mouse gene, mRTVP-1, as a p53 target gene. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 protein by two short in-frame deletions of two and nine amino acids. (mRTVP-1)
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 419, 849-853 (2002).
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 419, 853-857 (2002).
following stress-induced phosphorylation, p53 needs to form a complex with Pin1 and to undergo a conformational change to fulfil its biological roles
Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. Proc Natl Acad Sci U S A 100, 15095-15100 (2003).
p53 is required for sensitization to TRAIL
P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1. Proc Natl Acad Sci U S A 100, 15065-15070 (2003).
p53 mutants showed increased binding to NQO1, which can explain their resistance to dicoumarol-induced degradation, as NQO1 has an important role in stabilizing hot-spot p53 mutant proteins in cancer
Increased mdm-2 expression in a p53-independent manner blocks UV-induced cell cycle arrest and apoptosis in human osteosarcoma cells. Tumour Biol 24, 130-139 (2003).
P53 transcriptional activity is inhibited by MDM-2 overexpression, which blocks UV-induced cell cycle arrest and apoptosis
Activation of p53 by protein inhibitor of activated Stat1 (PIAS1). J Biol Chem 277, 8255-8259 (2002).
protein inhibitor of activated Stat1 (PIAS1) interacts with the tetramerization and C-terminal regulatory domains of p53 in yeast two-hybrid analyses
14-3-3 sigma positively regulates p53 and suppresses tumor growth. Mol Cell Biol 23, 7096-7107 (2003).
p53 activity is regulated by 14-3-3 sigma
Association of JNK1 with p21waf1 and p53: modulation of JNK1 activity. Mol Carcinog 36, 38-44 (2003).
association with JNK1 and p21waf1 modulates JNK1 activity
Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. Mol Cell Biol 23, 5556-5571 (2003).
there is a mitotic checkpoint wherein p53-dependent activation of Snk/Plk2 prevents mitotic catastrophe following spindle damage
p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice. Mol Cell Biol 22, 3247-3254 (2002).
These results demonstrate direct activation of the human DDB2 gene by p53. The corresponding region in the mouse DDB2 gene shared significant sequence identity with the human gene but was deficient for p53 binding and transcriptional activation.
Tumor suppressor p53 and its homologue p73alpha affect cell migration. J Biol Chem 278, 27362-27371 (2003).
p53 and p73alpha have roles in cell migration
Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells. J Biol Chem 277, 39266-39273 (2002).
p53 represses TauT and is involved in renal development and apoptosis.
Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. Oncogene 21, 4595-4600 (2002).
Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
MDMX inhibits the p300/CBP-mediated acetylation of p53. DNA Cell Biol 21, 519-525 (2002).
MDMX-mediated regulation of p53 activity during development.
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 278, 13595-13598 (2003).
Mdm2-mediated p53 ubiquitination is suppressed by HIF-1 alpha, which blocks Mdm2-mediated nuclear export of p53
The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth supp J Biol Chem 277, 10323-10331 (2002).
IkappaBalpha x p53 complex plays an important role in responses involving growth regulation, apoptosis, and hypoxic stress