OMIM :  600289

GENECARD : MAPK14

CGAP : 79107

• PRKM15
• Mxi2
• cytokine suppressive anti-inflammatory drug binding protein 2 (p38 MAP kinase)
• CSPB1
• CSBP1
• cytokine suppressive anti-inflammatory drug binding protein 1
• CSBP2
• p38
• PRKM14
• MAPK14

Function

• Breaking the balance between MEK/ERK and P38 MAP kinase signaling will modify pancreatic cancer cell proliferation. Ding XZ, Adrian TE.

• Activation of MAP kinases in growth responsive pancreatic cancer cells. Douziech N, Calvo E, Laine J, Morisset J.
   

Oncogenic activation

• MEK/ERK and P38 MAP kinase interaction is important for pancreatic cancer cell proliferation. Ding XZ, Adrian TE.

Signaling pathway

• In parallel with the stimulation of proliferation, blockade of P38 MAP kinase markedly induced MEK and ERK1/2 phosphorylation, indicating an interaction between MEK/ERK and P38 MAP kinase signaling. Ding XZ, Adrian TE.