OMIM :  177040

GENECARD : PRG1

CGAP : 1908

• PRG
• proteoglycan 1, secretory granule

Homologue  

• A homolog of p22/PRG1, designated IEX-1/DIF-2, exists. Schafer H, Lettau P, Trauzold A, Banasch M, Schmidt WE.
  

Function

• Human p22/PRG1 is a target gene for p53 and NFkappaB involved in growth regulation and stress response. Schafer H, Diebel J, Arlt A, Trauzold A, Schmidt WE.

Oncogenic Activity

• p22/PRG1 is expressed in various pancreatic carcinoma cells as a growth-associated early response gene. Schafer H, Lettau P, Trauzold A, Banasch M, Schmidt WE.
  PMID: 10231843 [PubMed - indexed for MEDLINE]

Protein Binding  

• Functional binding sites for the tumor suppressor p53 and for NFkappaB residing in the promoter of the novel human early response gene p22/PRG1 (IEX-1/DIF-2). Schafer H, Diebel J, Arlt A, Trauzold A, Schmidt WE.

Regulation

• p22/PRG1: a novel early response gene in pancreatic cancer cells regulated by p53 and NF kappa B. Schmidt WE, Arlt A, Trauzold A, Schafer H.